Head Coach: Jeff Walz Record: 29-8 (12-4 ACC)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | TV | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/06/2016 | H | Lindsey Wilson (Exhibition) | W | 97 | 50 | 1,927 | Louisville | Ky. | KFC Yum! Center | ||||||
| 11/11/2016 | A | Tennessee-Martin | W | 100 | 57 | 1-0 | 0-0 | 3,351 | Martin | Tenn. | Elam Center | ||||
| 11/13/2016 | H | Belmont | W | 73 | 50 | ACCN Extra | 2-0 | 0-0 | 8,347 | Louisville | Ky. | KFC Yum! Center | |||
| 11/16/2016 | A | Middle Tennessee | W | 91 | 72 | 3-0 | 0-0 | 4,516 | Murfreesboro | Tenn. | Charles Murphy Center | ||||
| 11/19/2016 | H | Bowling Green | W | 83 | 58 | ACCN Extra | 4-0 | 0-0 | 8,194 | Louisville | Ky. | KFC Yum! Center | 2016 Basketball Hall of Fame Women's Challenge | ||
| 11/20/2016 | H | Lafayette | W | 92 | 48 | ACCN Extra | 5-0 | 0-0 | 7,668 | Louisville | Ky. | KFC Yum! Center | 2016 Basketball Hall of Fame Women's Challenge | ||
| 11/21/2016 | H | Chattanooga | W | 63 | 47 | ACCN Extra | 6-0 | 0-0 | 7,719 | Louisville | Ky. | KFC Yum! Center | 2016 Basketball Hall of Fame Women's Challenge | ||
| 11/27/2016 | N | 3 | South Carolina | L | 59 | 83 | ESPN2 | 6-1 | 0-0 | 1,812 | Springfield | Mass. | MassMutual Center | 2016 Basketball Hall of Fame Women's Challenge | |
| 12/01/2016 | H | 5 | Maryland | L | 72 | 78 | ACCN Extra | 6-2 | 0-0 | 7,816 | Louisville | Ky. | KFC Yum! Center | 2016 ACC/Big Ten Challenge | |
| 12/04/2016 | H | 17 | Kentucky | W | 69 | 67 | OT | ACCN Extra | 7-2 | 0-0 | 12,245 | Louisville | Ky. | KFC Yum! Center | |
| 12/11/2016 | H | Western Kentucky | W | 68 | 61 | ACCN Extra | 8-2 | 0-0 | 9,168 | Louisville | Ky. | KFC Yum! Center | |||
| 12/14/2016 | H | South Dakota State | W | 83 | 30 | ACCN Extra | 9-2 | 0-0 | 7,408 | Louisville | Ky. | KFC Yum! Center | |||
| 12/16/2016 | H | College of Charleston | W | 86 | 58 | ACCN Extra | 10-2 | 0-0 | 7,567 | Louisville | Ky. | KFC Yum! Center | |||
| 12/18/2016 | H | Evansville | W | 89 | 47 | ACCN Extra | 11-2 | 0-0 | 8,320 | Louisville | Ky. | KFC Yum! Center | |||
| 12/21/2016 | A | Vanderbilt | W | 78 | 66 | SECN+ | 12-2 | 0-0 | 2,779 | Nashville | Tenn. | Memorial Gymnasium | |||
| 12/29/2016 | H | 25 | Syracuse | W | 91 | 76 | ACCN Extra | 13-2 | 1-0 | 8,586 | Louisville | Ky. | KFC Yum! Center | ||
| 01/02/2017 | A | 13 | Duke | L | 55 | 58 | ESPNU | 13-3 | 1-1 | 3,309 | Durham | N.C. | Cameron Indoor Stadium | ||
| 01/05/2017 | A | Virginia | W | 86 | 81 | OT | ACCN Extra | 14-3 | 2-1 | 2,490 | Charlottesville | Va. | JPJ Arena | ||
| 01/08/2017 | H | Pittsburgh | W | 73 | 52 | RSN/FOX | 15-3 | 3-1 | 8,039 | Louisville | Ky. | KFC Yum! Center | |||
| 01/12/2017 | A | 7 | Florida State | L | 65 | 72 | ACCN Extra | 15-4 | 3-2 | 4,092 | Tallahassee | Fla. | Tucker Center | ||
| 01/15/2017 | H | 14 | Miami, Fla. | W | 63 | 59 | ESPN2 | 16-4 | 4-2 | 10,016 | Louisville | Ky. | KFC Yum! Center | ||
| 01/18/2017 | H | Georgia Tech | W | 91 | 51 | ACCN Extra | 17-4 | 5-2 | 7,606 | Louisville | Ky. | KFC Yum! Center | |||
| 01/22/2017 | A | 23 | South Florida | W | 66 | 52 | ESPNU | 18-4 | 5-2 | 2,334 | Tampa | Fla. | Sun Dome | ||
| 01/26/2017 | A | Clemson | W | 60 | 46 | ACC Network Extra | 19-4 | 6-2 | 352 | Clemson | S.C. | Littlejohn Coliseum | |||
| 01/29/2017 | A | Pittsburgh | W | 63 | 48 | ACC Network Extra | 20-4 | 7-2 | 3,152 | Pittsburgh | Pa. | Petersen Events Center | |||
| 02/02/2017 | H | 19 | North Carolina State | L | 70 | 72 | OT | ACCN Extra | 20-5 | 7-3 | 8,251 | Louisville | Ky. | KFC Yum! Center | |
| 02/06/2017 | A | 7 | Notre Dame | L | 66 | 85 | ESPN2 | 20-6 | 7-4 | 8,325 | South Bend | Ind. | Purcell Pavilion | ||
| 02/09/2017 | A | Virginia Tech | W | 88 | 70 | ACCN Extra | 21-6 | 8-4 | 1,723 | Blacksburg | Va. | Cassell Coliseum | |||
| 02/12/2017 | H | Boston College | W | 68 | 43 | RSN/FOX | 22-6 | 9-4 | 9,306 | Louisville | Ky. | KFC Yum! Center | |||
| 02/19/2017 | H | North Carolina | W | 87 | 57 | ESPNU | 23-6 | 10-4 | 9,739 | Louisville | Ky. | KFC Yum! Center | |||
| 02/23/2017 | H | Virginia | W | 66 | 55 | ACCN Extra | 24-6 | 11-4 | 7,981 | Louisville | Ky. | KFC Yum! Center | |||
| 02/26/2017 | A | Wake Forest | W | 75 | 46 | ACCN Extra | 25-6 | 12-4 | 1,297 | Winston-Salem | N.C. | LJVM Coliseum | |||
| 03/02/2017 | N | Clemson | W | 68 | 46 | RSN/FOX | 26-6 | 12-4 | 2,613 | Conway | S.C. | HTC Center | 2017 ACC Tournament | ||
| 03/03/2017 | N | 17 | North Carolina State | W | 59 | 58 | RSN/FOX | 27-6 | 12-4 | 3,004 | Conway | S.C. | HTC Center | 2017 ACC Tournament | |
| 03/04/2017 | N | 3 | Notre Dame | L | 73 | 84 | ESPN2 | 27-7 | 12-4 | 3,600 | Conway | S.C. | HTC Center | 2017 ACC Tournament | |
| 03/18/2017 | H | Chattanooga | W | 82 | 62 | ESPN2 | 28-7 | 12-4 | 5,441 | Louisville | Ky. | KFC Yum! Center | 2017 NCAA Tournament First Round | ||
| 03/20/2017 | H | Tennessee | W | 75 | 64 | ESPN2 | 29-7 | 12-4 | 5,698 | Louisville | Ky. | KFC Yum! Center | 2017 NCAA Tournament Second Round | ||
| 03/24/2017 | N | 5 | Baylor | L | 63 | 97 | ESPN2 | 29-8 | 12-4 | 3,499 | Oklahoma City | Okla. | Chesapeake Arena | 2017 NCAA Tournament Sweet Sixteen |