Head Coach: Jeff Walz Record: 22-11 (13-5 ACC)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | TV | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/04/2024 | N | 5 | UCLA | L | 59 | 66 | 0-1 | 0-0 | 3,472 | 2024 Aflac Oui-Play | |||||
| 11/08/2024 | H | Southern Indiana | W | 75 | 51 | 1-1 | 0-0 | 7,666 | Louisville | Ky. | KFC Yum! Center | ||||
| 11/12/2024 | A | Tennessee-Martin | W | 86 | 64 | 2-1 | 0-0 | 1,453 | Martin | Tenn. | Kathleen and Tom Elam Center | ||||
| 11/16/2024 | A | 20 | Kentucky | L | 61 | 71 | OT | 2-2 | 0-0 | 6,117 | Lexington | Ky. | Memorial Coliseum | ||
| 11/21/2024 | H | Morehead State | W | 107 | 70 | 3-2 | 0-0 | 7,344 | Louisville | Ky. | KFC Yum! Center | ||||
| 11/24/2024 | N | South Florida | W | 64 | 60 | NBC Sports FAST Channel | 4-2 | 0-0 | Kissimmee | Fla. | State Farm Field House | 2024 WBCA State Farm Showcase | |||
| 11/30/2024 | A | Colorado | W | 79 | 71 | 5-2 | 0-0 | 3,487 | Boulder | Colo. | CU Events Center | ||||
| 12/04/2024 | H | 11 | Oklahoma | L | 72 | 78 | 5-3 | 0-0 | 7,446 | Louisville | Ky. | KFC Yum! Center | 2024 SEC/ACC Challenge | ||
| 12/07/2024 | N | 2 | Connecticut | L | 52 | 85 | 5-4 | 0-0 | 9,114 | Brooklyn | N.Y. | Barclays Center | 2024 Women's Champions Classic | ||
| 12/12/2024 | H | Grambling State | W | 96 | 57 | 6-4 | 0-0 | 7,395 | Louisville | Ky. | KFC Yum! Center | ||||
| 12/15/2024 | H | 22 | North Carolina State | L | 42 | 72 | 6-5 | 0-1 | 9,116 | Louisville | Ky. | KFC Yum! Center | |||
| 12/21/2024 | A | Memphis | W | 87 | 68 | 7-5 | 0-1 | 2,021 | Memphis | Tenn. | FedExForum | ||||
| 12/29/2024 | A | Boston College | W | 86 | 73 | 8-5 | 1-1 | 1,138 | Boston | Mass. | Conte Forum | ||||
| 01/02/2025 | H | Miami, Fla. | W | 74 | 56 | 9-5 | 2-1 | 7,956 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/05/2025 | A | Wake Forest | W | 81 | 76 | OT | 10-5 | 3-1 | 1,019 | Winston-Salem | N.C. | LJVM Coliseum | |||
| 01/09/2025 | A | Pittsburgh | W | 65 | 56 | 11-5 | 4-1 | 357 | Pittsburgh | Pa. | Petersen Events Center | ||||
| 01/12/2025 | H | 13 | Georgia Tech | W | 69 | 60 | 12-5 | 5-1 | 8,917 | Louisville | Ky. | KFC Yum! Center | |||
| 01/16/2025 | H | Syracuse | W | 72 | 62 | 13-5 | 6-1 | 7,442 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/19/2025 | A | Virginia Tech | L | 65 | 70 | 13-6 | 6-2 | 8,925 | Blacksburg | Va. | Cassell Coliseum | ||||
| 01/26/2025 | A | Virginia | W | 68 | 65 | 14-6 | 7-2 | 5,551 | Charlottesville | Va. | John Paul Jones Arena | ||||
| 01/30/2025 | A | Southern Methodist | W | 80 | 75 | 15-6 | 8-2 | 1,148 | Dallas | Texas | Moody Coliseum | ||||
| 02/02/2025 | H | 3 | Notre Dame | L | 71 | 89 | 15-7 | 8-3 | 11,603 | Louisville | Ky. | KFC Yum! Center | |||
| 02/06/2025 | H | 21 | California | W | 70 | 63 | 16-7 | 9-3 | 7,093 | Louisville | Ky. | KFC Yum! Center | |||
| 02/09/2025 | H | Stanford | W | 74 | 65 | 17-7 | 10-3 | 8,281 | Louisville | Ky. | KFC Yum! Center | ||||
| 02/13/2025 | A | 23 | Florida State | W | 83 | 69 | 18-7 | 11-3 | 1,913 | Tallahassee | Fla. | Donald L. Tucker Center | |||
| 02/20/2025 | A | 11 | Duke | W | 70 | 62 | 19-7 | 12-3 | 2,153 | Durham | N.C. | Cameron Indoor Stadium | |||
| 02/23/2025 | H | 9 | North Carolina | L | 75 | 79 | 19-8 | 12-4 | 11,280 | Louisville | Ky. | KFC Yum! Center | |||
| 02/27/2025 | H | Clemson | W | 78 | 52 | 20-8 | 13-4 | 7,881 | Louisville | Ky. | KFC Yum! Center | ||||
| 03/02/2025 | A | 3 | Notre Dame | L | 59 | 72 | 20-9 | 13-5 | 8,852 | Notre Dame | Ind. | Purcell Pavilion at the Joyce Center | |||
| 03/06/2025 | N | Clemson | W | 70 | 68 | OT | 21-9 | 13-5 | 5,828 | Greensboro | N.C. | First Horizon Coliseum | 2025 ACC Tournament | ||
| 03/07/2025 | N | 11 | Duke | L | 48 | 61 | 21-10 | 13-5 | 7,108 | Greensboro | N.C. | First Horizon Coliseum | 2025 ACC Tournament | ||
| 03/21/2025 | N | Nebraska | W | 63 | 58 | 22-10 | 13-5 | 6,464 | Fort Worth | Texas | Ed and Rae Schollmaier Arena | 2025 NCAA Tournament First Round | |||
| 03/23/2025 | A | 6 | Texas Christian | L | 70 | 85 | 22-11 | 13-5 | 7,494 | Fort Worth | Texas | Ed and Rae Schollmaier Arena | 2025 NCAA Tournament Second Round |