Head Coach: Jeff Walz Record: 34-5 (14-2 Big East)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/03/2008 | H | ASGR All-Stars (Exhibition) | W | 94 | 69 | |||||||||
| 11/08/2008 | A | Northern Kentucky (Exhibition) | W | 90 | 73 | |||||||||
| 11/15/2008 | A | Tennessee Tech | W | 82 | 49 | 1-0 | 0-0 | 1,121 | Cookeville | Tenn. | ||||
| 11/17/2008 | N | Austin Peay | W | 72 | 42 | 2-0 | 0-0 | 3,400 | Louisville | Ky. | Kicc | 2008 Game played in Kentucky International Convention Center | ||
| 11/22/2008 | A | 22 | Xavier | W | 65 | 55 | 3-0 | 0-0 | 2,132 | |||||
| 11/25/2008 | A | Utah | W | 59 | 48 | 4-0 | 0-0 | 2,382 | Salt Lake City | Utah | Huntsman Center | |||
| 11/28/2008 | N | Alabama | W | 73 | 56 | 5-0 | 0-0 | 393 | Reno | Nev. | Lawlor Events Center | 2008 Nugget Classic | ||
| 11/29/2008 | A | Nevada | L | 82 | 85 | 5-1 | 0-0 | 528 | Reno | Nev. | Lawlor Events Center | 2008 Nugget Classic | ||
| 12/04/2008 | A | Middle Tennessee | W | 67 | 44 | 6-1 | 0-0 | 4,021 | Murfreesboro | Tenn. | Murphy Center | |||
| 12/07/2008 | H | Ball State | W | 82 | 51 | 7-1 | 0-0 | 5,233 | Louisville | Ky. | Freedom Hall | |||
| 12/10/2008 | H | Hartford | W | 70 | 42 | 8-1 | 0-0 | 5,023 | Louisville | Ky. | Freedom Hall | |||
| 12/14/2008 | H | Kentucky | W | 75 | 59 | 9-1 | 0-0 | 16,337 | Louisville | Ky. | Freedom Hall | |||
| 12/21/2008 | H | Vermont | W | 67 | 56 | 10-1 | 0-0 | 5,045 | Louisville | Ky. | Freedom Hall | |||
| 12/28/2008 | H | Morehead State | W | 66 | 38 | 11-1 | 0-0 | 5,124 | Louisville | Ky. | Freedom Hall | 2008 Downtown Marriott Cardinal Classic | ||
| 12/29/2008 | H | Central Michigan | W | 95 | 72 | 12-1 | 0-0 | 5,093 | Louisville | Ky. | Freedom Hall | 2008 Downtown Marriott Cardinal Classic | ||
| 12/30/2008 | H | New Hampshire | W | 82 | 40 | 13-1 | 0-0 | 5,021 | Louisville | Ky. | Freedom Hall | 2008 Downtown Marriott Cardinal Classic | ||
| 01/03/2009 | H | DePaul | W | 78 | 60 | 14-1 | 1-0 | 5,345 | Louisville | Ky. | Freedom Hall | |||
| 01/06/2009 | H | Seton Hall | W | 76 | 47 | 15-1 | 2-0 | 5,048 | Louisville | Ky. | Freedom Hall | |||
| 01/11/2009 | H | 16 | Rutgers | W | 64 | 59 | 16-1 | 3-0 | 15,323 | Louisville | Ky. | Freedom Hall | ||
| 01/14/2009 | A | South Florida | W | 76 | 60 | 17-1 | 4-0 | 1,102 | USF Sun Dome; Tampa | Fla. | ||||
| 01/17/2009 | A | Georgetown | W | 74 | 58 | 18-1 | 5-0 | 909 | Washington | D.C. | ||||
| 01/20/2009 | H | Cincinnati | W | 66 | 50 | 19-1 | 6-0 | 5,045 | Louisville | Ky. | Freedom Hall | |||
| 01/26/2009 | A | 1 | Connecticut | L | 65 | 93 | 19-2 | 6-1 | 9,428 | Gampel Pavilion (Storrs Conn.) | ||||
| 01/31/2009 | A | Providence | W | 81 | 49 | 20-2 | 7-1 | 351 | Providence | R.I. | Alumni Hall | |||
| 02/03/2009 | H | Syracuse | W | 78 | 57 | 21-2 | 8-1 | 5,063 | Louisville | Ky. | Freedom Hall | |||
| 02/07/2009 | H | West Virginia | L | 70 | 79 | 21-3 | 8-2 | 7,453 | Louisville | Ky. | Freedom Hall | |||
| 02/11/2009 | A | 22 | Notre Dame | W | 71 | 66 | 22-3 | 9-2 | 6,706 | Notre Dame | Ind. | Joyce Center | ||
| 02/14/2009 | A | Cincinnati | W | 67 | 52 | 23-3 | 10-2 | 1,341 | ||||||
| 02/17/2009 | H | St. John's | W | 89 | 60 | 24-3 | 11-2 | 5,175 | Louisville | Ky. | Freedom Hall | |||
| 02/21/2009 | A | Villanova | W | 70 | 56 | 25-3 | 12-2 | 1,351 | ||||||
| 02/28/2009 | H | 15 | Pittsburgh | W | 75 | 51 | 26-3 | 13-2 | 11,335 | Louisville | Ky. | Freedom Hall | ||
| 03/02/2009 | A | Marquette | W | 66 | 61 | 27-3 | 14-2 | 1,704 | Milwaukee | Wis. | Al McGuire Center | |||
| 03/08/2009 | N | Rutgers | W | 87 | 82 | 2OT | 28-3 | 14-2 | 8,957 | XL Center Hartford | Conn. | 2009 BIG EAST Tournament | ||
| 03/09/2009 | N | 14 | Pittsburgh | W | 69 | 63 | 29-3 | 14-2 | 9,588 | XL Center Hartford | Conn. | 2009 BIG EAST Tournament | ||
| 03/10/2009 | N | 1 | Connecticut | L | 36 | 75 | 29-4 | 14-2 | 10,030 | XL Center Hartford | Conn. | 2009 BIG EAST Tournament | ||
| 03/22/2009 | N | Liberty | W | 62 | 42 | 30-4 | 14-2 | 3,610 | Baton Rouge | La. | Maravich Center | 2009 NCAA Tournament First Round | ||
| 03/24/2009 | A | Louisiana State | W | 62 | 52 | 31-4 | 14-2 | 3,651 | 2009 NCAA Tournament Second Round | |||||
| 03/28/2009 | N | 5 | Baylor | W | 56 | 39 | 32-4 | 14-2 | 2,820 | Raleigh | N.C. | RBC Center | 2009 NCAA Tournament Sweet Sixteen | |
| 03/30/2009 | N | 3 | Maryland | W | 77 | 60 | 33-4 | 14-2 | 2,659 | 2009 NCAA Tournament Elite Eight | ||||
| 04/05/2009 | N | 4 | Oklahoma | W | 61 | 59 | 34-4 | 14-2 | 18,621 | Saint Louis | Mo. | Scottrade Center | 2009 NCAA Tournament Final Four | |
| 04/07/2009 | N | 1 | Connecticut | L | 54 | 76 | 34-5 | 14-2 | 18,478 | Saint Louis | Mo. | Scottrade Center | 2009 NCAA Tournament Championship |