Head Coach: Jeff Walz Record: 26-8 (15-1 ACC)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | TV | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/15/2015 | H | California | L | 71 | 75 | 0-1 | 0-0 | 16,524 | Louisville | Ky. | KFC Yum! Center | |||
| 11/21/2015 | A | Western Kentucky | L | 69 | 71 | 0-2 | 0-0 | 3,176 | Bowling Green | Ky. | E.A. Diddle Arena | |||
| 11/27/2015 | N | Marist | W | 65 | 53 | 1-2 | 0-0 | 1,257 | Fort Myers | Fla. | Germain Arena | 2015 Gulf Coast Showcase | ||
| 11/28/2015 | N | Purdue | L | 60 | 62 | 1-3 | 0-0 | 1,407 | Fort Myers | Fla. | Germain Arena | 2015 Gulf Coast Showcase | ||
| 11/29/2015 | N | Dayton | L | 66 | 79 | 1-4 | 0-0 | 1,417 | Fort Myers | Fla. | Germain Arena | 2015 Gulf Coast Showcase | ||
| 12/03/2015 | A | 19 | Michigan State | W | 85 | 78 | 2-4 | 0-0 | 5,721 | East Lansing | Mich. | Breslin Center | 2015 ACC/Big Ten Challenge | |
| 12/05/2015 | H | Valparaiso | W | 75 | 42 | 3-4 | 0-0 | 8,274 | Louisville | Ky. | KFC Yum! Center | |||
| 12/10/2015 | A | 8 | Kentucky | L | 54 | 72 | 3-5 | 0-0 | 14,425 | Lexington | Ky. | Rupp Arena | ||
| 12/13/2015 | H | IUPUI | W | 70 | 61 | 4-5 | 0-0 | 8,686 | Louisville | Ky. | KFC Yum! Center | |||
| 12/15/2015 | H | Dartmouth | W | 94 | 52 | 5-5 | 0-0 | 7,971 | Louisville | Ky. | KFC Yum! Center | |||
| 12/18/2015 | A | Tennessee Tech | W | 76 | 54 | 6-5 | 0-0 | 943 | Cookeville | Tenn. | Eblen Center | |||
| 12/20/2015 | A | College of Charleston | W | 71 | 67 | 7-5 | 0-0 | 517 | Charleston | S.C. | TD Arena | |||
| 12/28/2015 | H | Tennessee-Martin | W | 88 | 66 | 8-5 | 0-0 | 8,690 | Louisville | Ky. | KFC Yum! Center | |||
| 01/01/2016 | H | 15 | Florida State | W | 79 | 69 | 9-5 | 1-0 | 9,126 | Louisville | Ky. | KFC Yum! Center | ||
| 01/03/2016 | A | Georgia Tech | W | 78 | 65 | 10-5 | 2-0 | 1,982 | Atlanta | Ga. | McCamish Pavilion | |||
| 01/07/2016 | H | Virginia Tech | W | 56 | 45 | 11-5 | 3-0 | 7,891 | Louisville | Ky. | KFC Yum! Center | |||
| 01/10/2016 | H | 18 | Duke | W | 65 | 48 | 12-5 | 4-0 | 11,342 | Louisville | Ky. | KFC Yum! Center | ||
| 01/14/2016 | A | Virginia | W | 59 | 41 | 13-5 | 5-0 | 2,880 | Charlottesville | Va. | JPJ Arena | |||
| 01/17/2016 | A | North Carolina State | W | 92 | 90 | 14-5 | 6-0 | 2,313 | Raleigh | N.C. | Holliday Gymnasium | |||
| 01/25/2016 | A | Syracuse | W | 71 | 53 | 15-5 | 7-0 | 549 | Syracuse | N.Y. | Carrier Dome | |||
| 01/28/2016 | H | Clemson | W | 75 | 33 | 16-5 | 8-0 | 8,379 | Louisville | Ky. | KFC Yum! Center | |||
| 01/31/2016 | H | Wake Forest | W | 78 | 54 | 17-5 | 9-0 | 9,673 | Louisville | Ky. | KFC Yum! Center | |||
| 02/04/2016 | A | North Carolina | W | 78 | 60 | 18-5 | 10-0 | 2,176 | Chapel Hill | N.C. | Carmichael Arena | |||
| 02/07/2016 | H | 3 | Notre Dame | L | 61 | 66 | 18-6 | 10-1 | 13,837 | Louisville | Ky. | KFC Yum! Center | ||
| 02/11/2016 | A | Pittsburgh | W | 84 | 61 | 19-6 | 11-1 | 806 | Pittsburgh | Pa. | Petersen Events Center | |||
| 02/15/2016 | H | 19 | South Florida | W | 67 | 50 | 20-6 | 11-1 | 7,941 | Louisville | Ky. | KFC Yum! Center | ||
| 02/18/2016 | H | Virginia | W | 74 | 59 | 21-6 | 12-1 | 8,736 | Louisville | Ky. | KFC Yum! Center | |||
| 02/21/2016 | A | Boston College | W | 55 | 45 | 22-6 | 13-1 | 1,454 | Chestnut Hill | Mass. | Silvio O. Conte Forum | |||
| 02/25/2016 | A | 17 | Miami, Fla. | W | 79 | 51 | 23-6 | 14-1 | 1,378 | Coral Gables | Fla. | BankUnited Center | ||
| 02/28/2016 | H | Pittsburgh | W | 65 | 36 | 24-6 | 15-1 | 11,641 | Louisville | Ky. | KFC Yum! Center | |||
| 03/04/2016 | N | Georgia Tech | W | 60 | 50 | 25-6 | 15-1 | 5,034 | Greensboro | N.C. | Greensboro Coliseum | 2016 ACC Tournament | ||
| 03/05/2016 | N | 17 | Syracuse | L | 75 | 80 | 25-7 | 15-1 | 6,361 | Greensboro | N.C. | Greensboro Coliseum | 2016 ACC Tournament | |
| 03/18/2016 | H | Central Arkansas | W | 87 | 60 | ESPN2 | 26-7 | 15-1 | 5,823 | Louisville | Ky. | KFC Yum! Center | 2016 NCAA Tournament First Round | |
| 03/20/2016 | H | 20 | DePaul | L | 72 | 73 | ESPN2 | 26-8 | 15-1 | 7,515 | Louisville | Ky. | KFC Yum! Center | 2016 NCAA Tournament Second Round |