Head Coach: Jeff Walz Record: 23-10 (10-6 Big East)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/30/2011 | H | Lindsey Wilson (Exhibition) | W | 118 | 41 | |||||||||
| 11/13/2011 | A | Missouri State | W | 73 | 64 | 1-0 | 0-0 | 3,802 | ||||||
| 11/15/2011 | A | 6 | Texas A&M | L | 58 | 76 | 1-1 | 0-0 | 6,943 | |||||
| 11/17/2011 | A | Eastern Kentucky | W | 77 | 53 | 2-1 | 0-0 | 2,800 | Richmond | Ky. | McBrayer Arena | |||
| 11/20/2011 | H | Xavier | W | 62 | 44 | 3-1 | 0-0 | 11,898 | Louisville | Ky. | KFC Yum! Center | |||
| 11/22/2011 | H | Austin Peay | W | 78 | 60 | 4-1 | 0-0 | 12,736 | Louisville | Ky. | KFC Yum! Center | |||
| 11/25/2011 | A | Florida State | W | 85 | 76 | 5-1 | 0-0 | 2,487 | Tallahassee | Fla. | Tucker Center | |||
| 11/26/2011 | A | Florida A&M | W | 86 | 66 | 6-1 | 0-0 | 577 | ||||||
| 11/29/2011 | H | Murray State | W | 105 | 62 | 7-1 | 0-0 | 8,112 | Louisville | Ky. | KFC Yum! Center | |||
| 12/04/2011 | A | 12 | Kentucky | L | 54 | 74 | 7-2 | 0-0 | 7,951 | Lexington | Ky. | Memorial Coliseum | ||
| 12/10/2011 | H | Gardner-Webb | W | 92 | 27 | 8-2 | 0-0 | 8,453 | Louisville | Ky. | KFC Yum! Center | |||
| 12/14/2011 | A | Cincinnati | W | 64 | 59 | 9-2 | 1-0 | 842 | Cincinnati | Ohio | Fifth Third Arena | |||
| 12/17/2011 | A | Portland | W | 71 | 42 | 10-2 | 1-0 | 3,211 | Portland | Ore. | Chiles Center | |||
| 12/19/2011 | A | Washington State | W | 75 | 71 | 11-2 | 1-0 | 2,019 | Pullman | Wash. | Beasley Coliseum | |||
| 12/28/2011 | H | Tennessee-Martin | W | 70 | 57 | 12-2 | 1-0 | 10,284 | Louisville | Ky. | KFC Yum! Center | |||
| 01/03/2012 | H | Marquette | W | 70 | 53 | 13-2 | 2-0 | 8,203 | Louisville | Ky. | KFC Yum! Center | |||
| 01/08/2012 | A | St. John's | L | 64 | 72 | 13-3 | 2-1 | 652 | Queens | N.Y. | Carnesecca Arena | |||
| 01/11/2012 | H | South Florida | W | 63 | 57 | 14-3 | 3-1 | 7,987 | Louisville | Ky. | KFC Yum! Center | |||
| 01/14/2012 | A | Rutgers | L | 68 | 71 | OT | 14-4 | 3-2 | 3,191 | |||||
| 01/18/2012 | H | Providence | W | 64 | 48 | 15-4 | 4-2 | 7,987 | Louisville | Ky. | KFC Yum! Center | |||
| 01/22/2012 | A | 19 | Georgetown | W | 64 | 61 | 16-4 | 5-2 | 1,289 | Washington | D.C. | McDonuogh Arena | ||
| 01/28/2012 | H | Villanova | W | 62 | 58 | 17-4 | 6-2 | 10,680 | Louisville | Ky. | KFC Yum! Center | |||
| 01/31/2012 | A | DePaul | L | 61 | 86 | 17-5 | 6-3 | 2,378 | ||||||
| 02/04/2012 | A | West Virginia | L | 50 | 66 | 17-6 | 6-4 | 4,537 | Morgantown | W.Va. | WVU Coliseum | |||
| 02/07/2012 | H | 3 | Connecticut | L | 46 | 56 | 17-7 | 6-5 | 16,483 | Louisville | Ky. | KFC Yum! Center | ||
| 02/11/2012 | H | Syracuse | W | 89 | 62 | 18-7 | 7-5 | 12,375 | Louisville | Ky. | KFC Yum! Center | |||
| 02/14/2012 | A | Pittsburgh | W | 71 | 66 | OT | 19-7 | 8-5 | 1,555 | Pittsburgh | Pa. | Petersen Events Center | ||
| 02/20/2012 | H | Notre Dame | L | 52 | 68 | 19-8 | 8-6 | 13,054 | Louisville | Ky. | KFC Yum! Center | |||
| 02/25/2012 | H | DePaul | W | 75 | 62 | 20-8 | 9-6 | 10,454 | Louisville | Ky. | KFC Yum! Center | |||
| 02/27/2012 | A | Seton Hall | W | 63 | 53 | 21-8 | 10-6 | 533 | ||||||
| 03/03/2012 | N | Villanova | W | 63 | 47 | 22-8 | 10-6 | 8,148 | XL Center Hartford | Conn. | 2012 BIG EAST Tournament | |||
| 03/04/2012 | N | 18 | St. John's | L | 61 | 68 | OT | 22-9 | 10-6 | 8,661 | XL Center Hartford | Conn. | 2012 BIG EAST Tournament | |
| 03/17/2012 | N | Michigan State | W | 67 | 55 | 23-9 | 10-6 | 5,624 | College Park | Md. | 2012 NCAA Tournament First Round | |||
| 03/19/2012 | A | 5 | Maryland | L | 68 | 72 | 23-10 | 10-6 | 4,857 | College Park | Md. | Comcast Center | 2012 NCAA Tournament Second Round |