Head Coach: Jeff Walz Record: 22-13 (10-6 Big East)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/30/2010 | H | Indiana Wesleyan (Exhibition) | W | 67 | 42 | ||||||||
| 11/12/2010 | H | 4 | Tennessee | L | 50 | 63 | 0-1 | 0-0 | 22,124 | Louisville | Ky. | KFC Yum! Center | |
| 11/14/2010 | A | Ohio | W | 84 | 47 | 1-1 | 0-0 | 1,026 | Athens | Ohio | Convocation Center | ||
| 11/17/2010 | H | Houston Baptist | W | 100 | 34 | 2-1 | 0-0 | 6,466 | Louisville | Ky. | KFC Yum! Center | ||
| 11/19/2010 | H | Southeast Missouri State | W | 97 | 43 | 3-1 | 0-0 | 6,705 | Louisville | Ky. | KFC Yum! Center | ||
| 11/23/2010 | A | 4 | Xavier | L | 59 | 71 | 3-2 | 0-0 | 3,461 | Cincinnati | Ohio | ||
| 11/26/2010 | A | Old Dominion | L | 65 | 69 | 3-3 | 0-0 | 3,038 | Norfolk | Va. | |||
| 11/29/2010 | A | IPFW | W | 100 | 79 | 4-3 | 0-0 | 416 | |||||
| 12/02/2010 | H | Mississippi Valley State | W | 96 | 37 | 5-3 | 0-0 | 6,405 | Louisville | Ky. | KFC Yum! Center | ||
| 12/05/2010 | H | 8 | Kentucky | W | 78 | 52 | 6-3 | 0-0 | 22,152 | Louisville | Ky. | KFC Yum! Center | |
| 12/11/2010 | H | Dayton | W | 69 | 55 | 7-3 | 0-0 | 8,613 | Louisville | Ky. | KFC Yum! Center | ||
| 12/15/2010 | A | Cincinnati | W | 78 | 40 | 8-3 | 1-0 | 362 | Cincinnati | Ohio | Fifth Third Arena | ||
| 12/18/2010 | N | Marist | L | 68 | 74 | 8-4 | 1-0 | 946 | Las Vegas | Nev. | Cox Pavilion | 2010 Duel in the Desert | |
| 12/19/2010 | N | Houston | L | 80 | 92 | 8-5 | 1-0 | 958 | Las Vegas | Nev. | Cox Pavilion | 2010 Duel in the Desert | |
| 12/20/2010 | N | Nebraska | W | 65 | 51 | 9-5 | 1-0 | 648 | Las Vegas | Nev. | Cox Pavillion | 2010 Duel in the Desert | |
| 12/28/2010 | H | Tennessee-Martin | W | 92 | 67 | 10-5 | 1-0 | 7,294 | Louisville | Ky. | KFC Yum! CENTER | ||
| 01/04/2011 | H | 18 | St. John's | W | 84 | 73 | 11-5 | 2-0 | 6,545 | Louisville | Ky. | KFC Yum! Center | |
| 01/09/2011 | H | Pittsburgh | W | 79 | 68 | 12-5 | 3-0 | 9,577 | Louisville | Ky. | KFC Yum! Center | ||
| 01/12/2011 | A | 12 | Notre Dame | L | 60 | 80 | 12-6 | 3-1 | 8,058 | Notre Dame | Ind. | Purcell Pavilion | |
| 01/15/2011 | A | 2 | Connecticut | L | 55 | 78 | 12-7 | 3-2 | 16,294 | ||||
| 01/22/2011 | H | Cincinnati | W | 83 | 47 | 13-7 | 4-2 | 10,556 | Louisville | Ky. | KFC Yum! Center | ||
| 01/26/2011 | A | Marquette | L | 65 | 76 | 13-8 | 4-3 | 1,222 | Milwaukee | Wis. | Al McGuire Center | ||
| 01/29/2011 | H | Rutgers | W | 56 | 45 | 14-8 | 5-3 | 15,061 | Louisville | Ky. | KFC Yum! Center | ||
| 02/01/2011 | H | 17 | Georgetown | L | 52 | 76 | 14-9 | 5-4 | 10,011 | Louisville | Ky. | KFC Yum! Center | |
| 02/06/2011 | A | Villanova | W | 64 | 48 | 15-9 | 6-4 | 1,563 | |||||
| 02/13/2011 | H | 17 | West Virginia | W | 57 | 47 | 16-9 | 7-4 | 12,251 | Louisville | Ky. | KFC Yum! Center | |
| 02/16/2011 | A | Syracuse | L | 45 | 53 | 16-10 | 7-5 | 1,343 | Syracuse | N.Y. | Carrier Dome | ||
| 02/19/2011 | A | South Florida | W | 66 | 55 | 17-10 | 8-5 | 683 | USF Sun Dome; Tampa | Fla. | |||
| 02/23/2011 | H | 7 | DePaul | W | 68 | 55 | 18-10 | 9-5 | 9,257 | Louisville | Ky. | KFC Yum! Center | |
| 02/26/2011 | H | Seton Hall | W | 59 | 49 | 19-10 | 10-5 | 9,875 | Louisville | Ky. | KFC Yum! Center | ||
| 02/28/2011 | A | Providence | L | 61 | 63 | 19-11 | 10-6 | 207 | Providence | R.I. | Alumni Hall | ||
| 03/05/2011 | N | Villanova | W | 69 | 47 | 20-11 | 10-6 | 8,246 | XL Center Hartford | Conn. | 2011 BIG EAST Tournament | ||
| 03/06/2011 | N | 7 | Notre Dame | L | 53 | 63 | 20-12 | 10-6 | 8,104 | XL Center Hartford | Conn. | 2011 BIG EAST Tournament | |
| 03/20/2011 | N | Vanderbilt | W | 81 | 62 | 21-12 | 10-6 | Cincinnati | Ohio | 2011 NCAA Tournament First Round | |||
| 03/22/2011 | A | 5 | Xavier | W | 85 | 75 | 22-12 | 10-6 | 4,065 | Cincinnati | Ohio | Cintas Center | 2011 NCAA Tournament Second Round |
| 03/26/2011 | N | 20 | Gonzaga | L | 69 | 76 | 22-13 | 10-6 | 11,339 | Spokane | Wash. | Spokane Arena | 2011 NCAA Tournament Sweet Sixteen |