Head Coach: Jeff Walz Record: 24-10 (12-6 ACC)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | TV | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/06/2023 | A | Cincinnati | W | 77 | 59 | 1-0 | 0-0 | 1,725 | Cincinnati | Ohio | Fifth Third Arena | |||
| 11/12/2023 | H | DePaul | W | 81 | 74 | 2-0 | 0-0 | 7,456 | Louisville | Ky. | KFC Yum! Center | |||
| 11/16/2023 | H | Bellarmine | W | 111 | 33 | 3-0 | 0-0 | 7,486 | Louisville | Ky. | KFC Yum! Center | |||
| 11/19/2023 | H | Bucknell | W | 77 | 44 | 4-0 | 0-0 | 7,383 | Louisville | Ky. | KFC Yum! Center | |||
| 11/24/2023 | N | Alabama | L | 73 | 78 | 4-1 | 0-0 | Katy | Texas | Leonard E. Merrell Center | 2023 Betty Chancellor Classic | |||
| 11/25/2023 | N | Liberty | W | 72 | 63 | 5-1 | 0-0 | 256 | Katy | Texas | Leonard E. Merrell Center | 2023 Betty Chancellor Classic | ||
| 11/26/2023 | N | Gonzaga | W | 81 | 70 | 6-1 | 0-0 | Katy | Texas | Leonard E. Merrell Center | 2023 Betty Chancellor Classic | |||
| 11/29/2023 | A | 19 | Mississippi | W | 64 | 58 | 7-1 | 0-0 | 2,694 | Oxford | Miss. | The Sandy and John Black Pavilion at Ole Miss | 2023 ACC/SEC Challenge | |
| 12/03/2023 | H | North Carolina A&T | W | 80 | 40 | 8-1 | 0-0 | 7,618 | Louisville | Ky. | KFC Yum! Center | |||
| 12/10/2023 | H | Kentucky | W | 73 | 61 | 9-1 | 0-0 | 11,291 | Louisville | Ky. | KFC Yum! Center | |||
| 12/13/2023 | H | Morehead State | W | 74 | 48 | 10-1 | 0-0 | 7,086 | Louisville | Ky. | KFC Yum! Center | |||
| 12/16/2023 | A | 17 | Connecticut | L | 62 | 86 | FOX | 10-2 | 0-0 | 13,028 | Hartford | Conn. | XL Center | |
| 12/20/2023 | H | 23 | Washington | W | 59 | 51 | 11-2 | 0-0 | 8,018 | Louisville | Ky. | KFC Yum! Center | ||
| 12/31/2023 | A | Miami, Fla. | W | 77 | 72 | 12-2 | 1-0 | 2,120 | Coral Gables | Fla. | Watsco Center | |||
| 01/04/2024 | H | Duke | W | 61 | 44 | 13-2 | 2-0 | 7,789 | Louisville | Ky. | KFC Yum! Center | |||
| 01/11/2024 | A | Pittsburgh | W | 74 | 44 | 14-2 | 3-0 | 868 | Pittsburgh | Pa. | Petersen Events Center | |||
| 01/14/2024 | H | Wake Forest | W | 83 | 62 | 15-2 | 4-0 | 8,901 | Louisville | Ky. | KFC Yum! Center | |||
| 01/18/2024 | A | Clemson | W | 81 | 64 | 16-2 | 5-0 | 868 | Clemson | S.C. | Littlejohn Coliseum | |||
| 01/21/2024 | A | 23 | North Carolina | L | 68 | 79 | 16-3 | 5-1 | 6,073 | Chapel Hill | N.C. | Carmichael Arena | ||
| 01/25/2024 | H | Boston College | W | 88 | 60 | 17-3 | 6-1 | 7,606 | Louisville | Ky. | KFC Yum! Center | |||
| 01/28/2024 | H | Pittsburgh | W | 77 | 58 | 18-3 | 7-1 | 9,452 | Louisville | Ky. | KFC Yum! Center | |||
| 02/01/2024 | H | 21 | Syracuse | W | 81 | 69 | 19-3 | 8-1 | 8,254 | Louisville | Ky. | KFC Yum! Center | ||
| 02/05/2024 | A | 3 | North Carolina State | L | 67 | 77 | 19-4 | 8-2 | 5,500 | Raleigh | N.C. | Reynolds Coliseum | ||
| 02/08/2024 | H | 12 | Notre Dame | W | 73 | 66 | ESPN | 20-4 | 9-2 | 9,417 | Louisville | Ky. | KFC Yum! Center | |
| 02/11/2024 | A | 23 | Syracuse | L | 72 | 73 | 20-5 | 9-3 | 3,912 | Syracuse | N.Y. | JMA Wireless Dome | ||
| 02/15/2024 | A | Boston College | W | 69 | 67 | 21-5 | 10-3 | 937 | Boston | Mass. | Conte Forum | |||
| 02/18/2024 | H | 12 | Virginia Tech | L | 70 | 86 | 21-6 | 10-4 | 12,249 | Louisville | Ky. | KFC Yum! Center | ||
| 02/22/2024 | A | Georgia Tech | W | 80 | 62 | 22-6 | 11-4 | 1,554 | Atlanta | Ga. | McCamish Pavilion | |||
| 02/25/2024 | H | Virginia | L | 68 | 73 | 22-7 | 11-5 | 10,305 | Louisville | Ky. | KFC Yum! Center | |||
| 02/29/2024 | H | Florida State | W | 70 | 55 | 23-7 | 12-5 | 7,932 | Louisville | Ky. | KFC Yum! Center | |||
| 03/03/2024 | A | 17 | Notre Dame | L | 58 | 74 | 23-8 | 12-6 | 9,149 | Notre Dame | Ind. | Purcell Pavilion at the Joyce Center | ||
| 03/07/2024 | N | Boston College | W | 58 | 55 | 24-8 | 12-6 | Greensboro | N.C. | Greensboro Coliseum | 2024 ACC Tournament | |||
| 03/08/2024 | N | 14 | Notre Dame | L | 68 | 77 | 24-9 | 12-6 | Greensboro | N.C. | Greensboro Coliseum | 2024 ACC Tournament | ||
| 03/22/2024 | N | Middle Tennessee | L | 69 | 71 | 24-10 | 12-6 | Baton Rouge | La. | Maravich Assembly Center | 2024 NCAA Tournament First Round |