Head Coach: Tom Collen Record: 27-8 (10-6 Big East)
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/03/2006 | H | Hoosier Lady Stars (Exhibition) | W | 83 | 79 | ||||||||||
| 11/10/2006 | H | Dayton | W | 81 | 54 | 1-0 | 0-0 | 2,536 | Louisville | Ky. | Knights Hall | 2006 Cardinal Classic | |||
| 11/11/2006 | H | Winthrop | W | 69 | 45 | 2-0 | 0-0 | 1,986 | Louisville | Ky. | Knights Hall | 2006 Cardinal Classic | |||
| 11/12/2006 | H | Memphis | W | 102 | 64 | 3-0 | 0-0 | 1,935 | Louisville | Ky. | Knights Hall | 2006 Cardinal Classic | |||
| 11/19/2006 | H | Furman | W | 89 | 44 | 4-0 | 0-0 | 1,555 | Louisville | Ky. | Freedom Hall | ||||
| 11/24/2006 | A | UC Santa Barbara | W | 72 | 66 | 5-0 | 0-0 | 1,052 | Santa Barbara | Calif. | The Thunderdome | ||||
| 11/26/2006 | A | Northern Colorado | 24 | W | 82 | 52 | 6-0 | 0-0 | 542 | Greeley | Colo. | Butler-Hancock SP | |||
| 11/30/2006 | A | Xavier | W | 63 | 59 | 7-0 | 0-0 | 1,055 | Cincinnati | Ohio | Cintas Center | ||||
| 12/03/2006 | H | Kentucky | W | 83 | 75 | 8-0 | 0-0 | 12,342 | Louisville | Ky. | Freedom Hall | ||||
| 12/09/2006 | H | Western Kentucky | W | 70 | 58 | 9-0 | 0-0 | 5,325 | Louisville | Ky. | Freedom Hall | ||||
| 12/14/2006 | H | Cincinnati | W | 67 | 62 | 10-0 | 1-0 | 1,567 | Louisville | Ky. | Freedom Hall | ||||
| 12/16/2006 | H | Belmont | W | 80 | 51 | 11-0 | 1-0 | 1,336 | Louisville | Ky. | Freedom Hall | ||||
| 12/18/2006 | H | Butler | W | 80 | 77 | 12-0 | 1-0 | 1,846 | Louisville | Ky. | Freedom Hall | ||||
| 12/21/2006 | A | Florida | W | 77 | 60 | 13-0 | 1-0 | 1,011 | |||||||
| 12/29/2006 | H | Eastern Illinois | W | 93 | 75 | 14-0 | 1-0 | 2,527 | Louisville | Ky. | Freedom Hall | ||||
| 12/31/2006 | H | Sacramento State | W | 77 | 42 | 15-0 | 1-0 | 2,381 | Louisville | Ky. | Freedom Hall | ||||
| 01/03/2007 | A | Providence | 13 | L | 94 | 106 | 2OT | 15-1 | 1-1 | 303 | Providence | R.I. | Alumni Hall | ||
| 01/06/2007 | H | Seton Hall | W | 88 | 67 | 16-1 | 2-1 | 2,242 | Louisville | Ky. | Freedom Hall | ||||
| 01/09/2007 | A | Georgetown | W | 57 | 54 | 17-1 | 3-1 | 562 | |||||||
| 01/16/2007 | A | South Florida | 15 | L | 58 | 74 | 17-2 | 3-2 | 845 | Tampa | Fla. | Sun Dome | |||
| 01/21/2007 | H | Rutgers | W | 53 | 50 | 18-2 | 4-2 | 3,258 | Louisville | Ky. | Freedom Hall | ||||
| 01/24/2007 | H | Pittsburgh | W | 72 | 59 | 19-2 | 5-2 | 2,288 | Louisville | Ky. | Freedom Hall | ||||
| 01/30/2007 | A | Villanova | 19 | W | 64 | 59 | 20-2 | 6-2 | 669 | ||||||
| 02/03/2007 | H | DePaul | W | 86 | 68 | 21-2 | 7-2 | 2,547 | Louisville | Ky. | Freedom Hall | ||||
| 02/07/2007 | A | Notre Dame | L | 55 | 64 | 21-3 | 7-3 | 5,672 | Notre Dame | Ind. | Joyce Center | ||||
| 02/10/2007 | H | Syracuse | W | 98 | 50 | 22-3 | 8-3 | 4,012 | Louisville | Ky. | Freedom Hall | ||||
| 02/13/2007 | A | Connecticut | L | 56 | 84 | 22-4 | 8-4 | 9,487 | |||||||
| 02/17/2007 | A | 21 | Marquette | 20 | L | 54 | 65 | 22-5 | 8-5 | 2,809 | Milwaukee | Wis. | Al McGuire Center | ||
| 02/20/2007 | H | St. John's | W | 91 | 62 | 23-5 | 9-5 | 1,933 | Louisville | Ky. | Freedom Hall | ||||
| 02/24/2007 | A | Syracuse | 23 | W | 68 | 56 | 24-5 | 10-5 | 485 | Syracuse | N.Y. | Carrier Dome | |||
| 02/26/2007 | H | West Virginia | L | 71 | 76 | OT | 24-6 | 10-6 | 4,249 | Louisville | Ky. | Freedom Hall | |||
| 03/03/2007 | N | St. John's | W | 68 | 54 | 25-6 | 10-6 | Hartford Civic Center Hartford | Conn. | 2007 BIG EAST Tournament | |||||
| 03/04/2007 | N | West Virginia | W | 68 | 56 | 26-6 | 10-6 | Hartford Civic Center Hartford | Conn. | 2007 BIG EAST Tournament | |||||
| 03/05/2007 | N | Connecticut | L | 50 | 76 | 26-7 | 10-6 | Hartford Civic Center Hartford | Conn. | 2007 BIG EAST Tournament | |||||
| 03/17/2007 | N | Brigham Young | W | 80 | 54 | 27-7 | 10-6 | Los Angeles | Calif. | Galen Center | 2007 NCAA Tournament First Round | ||||
| 03/19/2007 | N | Arizona State | L | 58 | 67 | 27-8 | 10-6 | 1,209 | Los Angeles | Calif. | Galen Center | 2007 NCAA Tournament Second Round |