Head Coach: Jeff Walz Record: 26-12 (12-6 ACC)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | TV | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/07/2022 | H | Cincinnati | W | 87 | 68 | 1-0 | 0-0 | 8,049 | Louisville | Ky. | KFC Yum! Center | ||||
| 11/10/2022 | H | IUPUI | W | 84 | 62 | 2-0 | 0-0 | 7,436 | Louisville | Ky. | KFC Yum! Center | ||||
| 11/13/2022 | A | Belmont | W | 75 | 70 | 3-0 | 0-0 | 1,840 | Nashville | Tenn. | Curb Event Center | ||||
| 11/19/2022 | N | Gonzaga | L | 67 | 79 | OT | FloHoops ($) | 3-1 | 0-0 | 421 | Paradise Island | Bahamas | Atlantis Resort | 2022 ACC Tournament | |
| 11/20/2022 | N | 3 | Texas | W | 71 | 63 | FloHoops ($) | 4-1 | 0-0 | 365 | Paradise Island | Bahamas | Atlantis Resort | 2022 ACC Tournament | |
| 11/21/2022 | N | South Dakota State | L | 55 | 65 | FloHoops ($) | 4-2 | 0-0 | 215 | Paradise Island | Bahamas | Atlantis Resort | 2022 Battle 4 Atlantis | ||
| 11/25/2022 | H | Longwood | W | 100 | 37 | 5-2 | 0-0 | 8,130 | Louisville | Ky. | KFC Yum! Center | ||||
| 11/30/2022 | H | 4 | Ohio State | L | 77 | 96 | 5-3 | 0-0 | 8,259 | Louisville | Ky. | KFC Yum! Center | 2022 ACC/Big 10 Challenge | ||
| 12/04/2022 | A | Middle Tennessee | L | 49 | 67 | 5-4 | 0-0 | 5,307 | Murfreesboro | Tenn. | Murphy Center | ||||
| 12/06/2022 | H | Southern Illinois-Edwardsville | W | 105 | 32 | 6-4 | 0-0 | 7,311 | Louisville | Ky. | KFC Yum! Center | ||||
| 12/11/2022 | A | Kentucky | W | 86 | 72 | 7-4 | 0-0 | 7,927 | Lexington | Ky. | Rupp Arena | ||||
| 12/14/2022 | A | Bellarmine | W | 73 | 43 | 8-4 | 0-0 | 2,676 | Louisville | Ky. | Freedom Hall | ||||
| 12/18/2022 | A | Pittsburgh | W | 77 | 53 | 9-4 | 1-0 | 491 | Pittsburgh | Pa. | Petersen Events Center | ||||
| 12/21/2022 | A | DePaul | W | 81 | 67 | 10-4 | 1-0 | 1,422 | Chicago | Ill. | Wintrust Arena | ||||
| 12/29/2022 | H | Syracuse | W | 86 | 77 | 11-4 | 2-0 | 9,025 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/01/2023 | A | Duke | L | 56 | 63 | RSN | 11-5 | 2-1 | 1,720 | Durham | N.C. | Cameron Indoor Stadium | |||
| 01/05/2023 | H | Georgia Tech | W | 63 | 55 | 12-5 | 3-1 | 7,633 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/08/2023 | H | Pittsburgh | W | 76 | 69 | 13-5 | 4-1 | 9,218 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/12/2023 | A | 13 | Virginia Tech | L | 79 | 81 | 13-6 | 4-2 | 2,328 | Blacksburg | Va. | Cassell Coliseum | |||
| 01/15/2023 | A | Florida State | W | 82 | 75 | RSN | 14-6 | 5-2 | 2,544 | Tallahassee | Fla. | Donald L. Tucker Center | |||
| 01/19/2023 | H | Boston College | W | 73 | 65 | 15-6 | 6-2 | 7,592 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/22/2023 | H | 20 | North Carolina State | L | 51 | 63 | 15-7 | 6-3 | 11,175 | Louisville | Ky. | KFC Yum! Center | |||
| 01/26/2023 | A | Wake Forest | L | 57 | 68 | 15-8 | 6-4 | 857 | Winston-Salem | N.C. | LJVM Coliseum | ||||
| 01/29/2023 | A | Syracuse | W | 79 | 67 | 16-8 | 7-4 | 6,220 | Syracuse | N.Y. | JMA Wireless Dome | ||||
| 02/05/2023 | H | 11 | North Carolina | W | 62 | 55 | 17-8 | 8-4 | 10,069 | Louisville | Ky. | KFC Yum! Center | |||
| 02/09/2023 | A | Virginia | W | 63 | 53 | 18-8 | 9-4 | 3,008 | Charlottesville | Va. | John Paul Jones Arena | ||||
| 02/12/2023 | H | Clemson | W | 81 | 69 | 19-8 | 10-4 | 8,782 | Louisville | Ky. | KFC Yum! Center | ||||
| 02/16/2023 | A | 10 | Notre Dame | L | 76 | 78 | OT | 19-9 | 10-5 | 5,245 | Notre Dame | Ind. | Purcell Pavilion at the Joyce Center | ||
| 02/19/2023 | A | Boston College | W | 62 | 52 | 20-9 | 11-5 | 1,423 | Boston | Mass. | Conte Forum | ||||
| 02/23/2023 | H | Miami, Fla. | W | 71 | 57 | 21-9 | 12-5 | 8,211 | Louisville | Ky. | KFC Yum! Center | ||||
| 02/26/2023 | H | 10 | Notre Dame | L | 65 | 68 | 21-10 | 12-6 | 12,015 | Louisville | Ky. | KFC Yum! Center | |||
| 03/03/2023 | N | Wake Forest | W | 74 | 48 | 22-10 | 12-6 | Greensboro | N.C. | Greensboro Coliseum Complex | 2023 ACC Tournament | ||||
| 03/04/2023 | N | 10 | Notre Dame | W | 64 | 38 | 23-10 | 12-6 | Greensboro | N.C. | Greensboro Coliseum Complex | 2023 ACC Tournament | |||
| 03/05/2023 | N | 8 | Virginia Tech | L | 67 | 75 | 23-11 | 12-6 | 6,802 | Greensboro | N.C. | Greensboro Coliseum Complex | 2023 ACC Tournament | ||
| 03/18/2023 | N | Drake | W | 83 | 81 | 24-11 | 12-6 | Austin | Texas | Moody Center | 2023 NCAA Tournament First Round | ||||
| 03/20/2023 | A | 15 | Texas | W | 73 | 51 | 25-11 | 12-6 | 5,430 | Austin | Texas | Moody Center | 2023 NCAA Tournament Second Round | ||
| 03/24/2023 | N | Mississippi | W | 72 | 62 | 26-11 | 12-6 | 9,626 | Seattle | Wash. | Climate Pledge Arena | 2023 NCAA Tournament Sweet Sixteen | |||
| 03/26/2023 | N | 3 | Iowa | L | 83 | 97 | 26-12 | 12-6 | 11,700 | Seattle | Wash. | Climate Pledge Arena | 2023 NCAA Tournament Elite Eight |