Head Coach: Tom Collen Record: 22-9 (11-3 C-USA)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/13/2004 | H | Hoosier Lady Stars (Exhibition) | W | 65 | 52 | |||||||||
| 11/19/2004 | A | Vermont | L | 56 | 59 | 0-1 | 0-0 | 800 | Burlington | Vt. | 2004 Northbank Classic | |||
| 11/20/2004 | N | Auburn | W | 76 | 60 | 1-1 | 0-0 | 2,004 | Burlington | Vt. | Patrick Gymnasium | 2004 Northbank Classic | ||
| 11/26/2004 | N | Hampton | W | 63 | 55 | 2-1 | 0-0 | 1,643 | St. Thomas | U.S. Virgin Islands | 2004 Paradise Jam | |||
| 11/27/2004 | N | 25 | North Carolina State | L | 49 | 54 | 2-2 | 0-0 | 2,097 | St. Thomas | U.S. Virgin Islands | 2004 Paradise Jam | ||
| 12/03/2004 | A | Indiana | L | 57 | 61 | 2-3 | 0-0 | 1,279 | Bloomington | Ind. | Assembly Hall | |||
| 12/05/2004 | H | Kentucky | W | 66 | 49 | 3-3 | 0-0 | 3,427 | Louisville | Ky. | Freedom Hall | |||
| 12/08/2004 | H | Detroit Mercy | W | 69 | 54 | 4-3 | 0-0 | 878 | Louisville | Ky. | Freedom Hall | |||
| 12/12/2004 | H | Western Kentucky | W | 78 | 68 | 5-3 | 0-0 | 2,896 | Louisville | Ky. | Freedom Hall | |||
| 12/16/2004 | H | Alabama State | W | 77 | 46 | 6-3 | 0-0 | 612 | Louisville | Ky. | Freedom Hall | |||
| 12/19/2004 | H | Murray State | W | 97 | 45 | 7-3 | 0-0 | 828 | Louisville | Ky. | Freedom Hall | |||
| 12/22/2004 | A | Xavier | W | 64 | 61 | 8-3 | 0-0 | 642 | ||||||
| 12/28/2004 | N | 19 | Florida State | L | 54 | 69 | 8-4 | 0-0 | 917 | Missoula | Mont. | Dahlberg Arena | 2004 Lady Griz Classic | |
| 12/29/2004 | N | Maine | W | 69 | 57 | 9-4 | 0-0 | 1,091 | Missoula | Mont. | Dahlberg Arena | 2004 Lady Griz Classic | ||
| 01/07/2005 | A | South Florida | L | 59 | 67 | 9-5 | 0-1 | 1,346 | USF Sun Dome - Tampa | Fla. | ||||
| 01/09/2005 | A | Alabama-Birmingham | W | 74 | 59 | 10-5 | 1-1 | 345 | Bartow Arena; Birmingham | Ala. | ||||
| 01/16/2005 | A | Cincinnati | W | 72 | 71 | 11-5 | 2-1 | 512 | Cincinnati | Ohio | Fifth Third Arena | |||
| 01/21/2005 | H | Texas Christian | W | 63 | 57 | 12-5 | 3-1 | 1,504 | Louisville | Ky. | Freedom Hall | |||
| 01/23/2005 | H | Houston | W | 50 | 49 | 13-5 | 4-1 | 2,196 | Louisville | Ky. | Freedom Hall | |||
| 01/28/2005 | A | Memphis | W | 75 | 68 | 14-5 | 5-1 | 965 | ||||||
| 01/30/2005 | A | Saint Louis | W | 72 | 55 | 15-5 | 6-1 | 413 | St. Louis | Mo. | Bauman-Eberhardt Ctr. | |||
| 02/05/2005 | H | 17 | DePaul | L | 60 | 70 | 15-6 | 6-2 | 2,872 | Louisville | Ky. | Freedom Hall | ||
| 02/07/2005 | H | Marquette | W | 70 | 56 | 16-6 | 7-2 | 1,283 | Louisville | Ky. | Freedom Hall | |||
| 02/11/2005 | A | Charlotte | W | 63 | 60 | OT | 17-6 | 8-2 | 1,425 | Charlotte | N.C. | Halton Arena | ||
| 02/13/2005 | A | East Carolina | L | 65 | 71 | OT | 17-7 | 8-3 | 956 | Greenville | N.C. | Minges Coliseum | ||
| 02/18/2005 | H | Southern Mississippi | W | 80 | 65 | 18-7 | 9-3 | 1,005 | Louisville | Ky. | Cardinal Arena | |||
| 02/20/2005 | H | Tulane | W | 70 | 51 | 19-7 | 10-3 | 2,777 | Louisville | Ky. | Freedom Hall | |||
| 02/25/2005 | H | Cincinnati | W | 61 | 58 | 20-7 | 11-3 | 1,004 | Louisville | Ky. | Cardinal Arena | |||
| 03/04/2005 | N | Marquette | W | 69 | 54 | 21-7 | 11-3 | 2,680 | Charlotte | N.C. | Halton Arena | 2005 C-USA Tournament | ||
| 03/05/2005 | N | Houston | W | 56 | 48 | 22-7 | 11-3 | 1,801 | Charlotte | N.C. | Halton Arena | 2005 C-USA Tournament | ||
| 03/06/2005 | N | Texas Christian | L | 41 | 60 | 22-8 | 11-3 | 2,014 | Charlotte | N.C. | Halton Arena | 2005 C-USA Tournament | ||
| 03/19/2005 | N | Southern California | L | 49 | 65 | 22-9 | 11-3 | Minneapolis | Minn. | 2005 NCAA Tournament First Round |