Head Coach: Jeff Walz Record: 29-9 (11-5 Big East)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/31/2012 | H | Eckerd (Exhibition) | W | 83 | 29 | |||||||||
| 11/09/2012 | H | 15 | Texas A&M | W | 47 | 45 | 1-0 | 0-0 | 10,896 | Louisville | Ky. | KFC Yum! Center | ||
| 11/11/2012 | H | Portland | W | 95 | 48 | 2-0 | 0-0 | 6,423 | Louisville | Ky. | KFC Yum! Center | |||
| 11/15/2012 | A | Austin Peay | W | 90 | 52 | 3-0 | 0-0 | 826 | Clarksville | Tenn. | Dunn Center | |||
| 11/20/2012 | N | Central Florida | W | 94 | 73 | 4-0 | 0-0 | 136 | Puerto Vallarta | Mexico | 2012 Hardwood Tournament of Hope Puerto | |||
| 11/21/2012 | N | Gonzaga | W | 55 | 42 | 5-0 | 0-0 | 167 | Puerto Vallarta | Mexico | 2012 Hardwood Tournament of Hope Puerto | |||
| 11/22/2012 | N | Oregon State | W | 61 | 43 | 6-0 | 0-0 | 224 | Puerto Vallarta | Mexico | Con. Center | 2012 Hardwood Tournament of Hope Puerto | ||
| 11/26/2012 | A | Tennessee-Martin | W | 79 | 61 | 7-0 | 0-0 | 3,223 | ||||||
| 11/28/2012 | H | Eastern Kentucky | W | 76 | 42 | 8-0 | 0-0 | 7,942 | Louisville | Ky. | KFC Yum! Center | |||
| 12/02/2012 | H | 9 | Kentucky | L | 47 | 48 | 8-1 | 0-0 | 15,453 | Louisville | Ky. | KFC Yum! Center | ||
| 12/08/2012 | H | Valparaiso | W | 96 | 40 | 9-1 | 0-0 | 7,856 | KFC Yum! Center | |||||
| 12/14/2012 | A | Colorado | L | 66 | 70 | 9-2 | 0-0 | 3,408 | ||||||
| 12/18/2012 | H | Washington State | W | 75 | 39 | 10-2 | 0-0 | 7,341 | Louisville | Ky. | KFC Yum! Center | |||
| 12/21/2012 | H | Wagner | W | 106 | 32 | 11-2 | 0-0 | 7,876 | Louisville | Ky. | KFC Yum! Center | |||
| 12/31/2012 | H | Tennessee State | W | 88 | 25 | 12-2 | 0-0 | 9,023 | Louisville | Ky. | KFC Yum! Center | |||
| 01/05/2013 | A | DePaul | L | 80 | 86 | 12-3 | 0-1 | 3,212 | ||||||
| 01/08/2013 | H | Rutgers | W | 66 | 57 | OT | 13-3 | 1-1 | 9,557 | Louisville | Ky. | KFC Yum! Center | ||
| 01/12/2013 | A | Providence | W | 70 | 62 | 14-3 | 2-1 | 681 | Providence | R.I. | Alumni Hall | |||
| 01/15/2013 | A | 3 | Connecticut | L | 58 | 72 | 14-4 | 2-2 | 8,702 | |||||
| 01/18/2013 | H | Cincinnati | W | 72 | 33 | 15-4 | 3-2 | 9,752 | Louisville | Ky. | KFC Yum! Center | |||
| 01/22/2013 | A | Marquette | W | 64 | 63 | 16-4 | 4-2 | 1,189 | Al McGuire Center | |||||
| 01/27/2013 | H | St. John's | W | 57 | 54 | 17-4 | 5-2 | 11,543 | Louisville | Ky. | KFC Yum! Center | |||
| 01/30/2013 | A | South Florida | W | 78 | 75 | 18-4 | 6-2 | 1,227 | Sun Dome | |||||
| 02/02/2013 | H | Georgetown | W | 74 | 60 | 19-4 | 7-2 | 10,495 | Louisville | Ky. | KFC Yum! Center | |||
| 02/09/2013 | H | Pittsburgh | W | 78 | 45 | 20-4 | 8-2 | 10,733 | Louisville | Ky. | KFC Yum! Center | |||
| 02/11/2013 | A | 2 | Notre Dame | L | 64 | 93 | 20-5 | 8-3 | 8,368 | Notre Dame | Ind. | Purcell Pavilion | ||
| 02/17/2013 | H | DePaul | W | 81 | 55 | 21-5 | 9-3 | 10,906 | Louisville | Ky. | KFC Yum! Center | |||
| 02/20/2013 | H | South Florida | L | 62 | 73 | 21-6 | 9-4 | 8,201 | Louisville | Ky. | KFC Yum! Center | |||
| 02/24/2013 | A | Villanova | W | 55 | 49 | 22-6 | 10-4 | 1,239 | ||||||
| 02/27/2013 | H | Seton Hall | W | 72 | 62 | 23-6 | 11-4 | 9,232 | Louisville | Ky. | KFC Yum! Center | |||
| 03/04/2013 | A | 24 | Syracuse | L | 57 | 68 | 23-7 | 11-5 | 441 | Syracuse | N.Y. | Carrier Dome | ||
| 03/10/2013 | N | St. John's | W | 62 | 55 | 24-7 | 11-5 | 2,013 | XL Center Hartford | Conn. | 2013 BIG EAST Tournament | |||
| 03/11/2013 | N | 2 | Notre Dame | L | 59 | 83 | 24-8 | 11-5 | 7,621 | Hartford | Conn. | XL Center | 2013 BIG EAST Tournament | |
| 03/24/2013 | H | Middle Tennessee | W | 74 | 49 | 25-8 | 11-5 | 5,977 | Louisville | Ky. | KFC Yum! Center | 2013 NCAA Tournament First Round | ||
| 03/26/2013 | H | 21 | Purdue | W | 76 | 63 | 26-8 | 11-5 | 9,236 | Louisville | Ky. | KFC Yum! Center | 2013 NCAA Tournament Second Round | |
| 03/31/2013 | N | 1 | Baylor | W | 82 | 81 | 27-8 | 11-5 | 9,162 | 2013 NCAA Tournament Sweet Sixteen | ||||
| 04/02/2013 | N | 10 | Tennessee | W | 86 | 78 | 28-8 | 11-5 | 6,147 | 2013 NCAA Tournament Elite Eight | ||||
| 04/07/2013 | N | 6 | California | W | 64 | 57 | 29-8 | 11-5 | New Orleans | La. | New Orleans Arena | 2013 NCAA Tournament Final Four | ||
| 04/09/2013 | N | 3 | Connecticut | L | 60 | 93 | 29-9 | 11-5 | 17,545 | New Orleans | La. | New Orleans Arena | 2013 NCAA Tournament Championship |