Head Coach: Jeff Walz Record: 14-18 (5-11 Big East)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/01/2009 | H | Northern Kentucky (Exhibition) | W | 79 | 54 | |||||||||
| 11/15/2009 | A | Dayton | W | 65 | 63 | 1-0 | 0-0 | 1,197 | UD Arena | |||||
| 11/17/2009 | A | Hartford | L | 50 | 62 | 1-1 | 0-0 | 2,017 | West Hartford | Conn. | Chase Arena | |||
| 11/22/2009 | H | Tennessee Tech | W | 84 | 54 | 2-1 | 0-0 | 5,793 | Louisville | Ky. | Freedom Hall | |||
| 11/27/2009 | N | Northern Iowa | W | 81 | 53 | 3-1 | 0-0 | 198 | 2009 Cancun Thanksgiving Classic | |||||
| 11/28/2009 | N | Old Dominion | W | 82 | 75 | 4-1 | 0-0 | 278 | 2009 Cancun Thanksgiving Classic | |||||
| 12/02/2009 | A | Central Michigan | L | 75 | 84 | 4-2 | 0-0 | 625 | Mount Pleasant | Mich. | Rose Center | |||
| 12/06/2009 | H | Utah | W | 60 | 55 | 5-2 | 0-0 | 8,213 | Louisville | Ky. | Freedom Hall | |||
| 12/09/2009 | H | Middle Tennessee | L | 84 | 94 | 5-3 | 0-0 | 5,712 | Louisville | Ky. | Freedom Hall | |||
| 12/13/2009 | H | IUPUI | W | 88 | 58 | 6-3 | 0-0 | 6,021 | Louisville | Ky. | Freedom Hall | |||
| 12/16/2009 | A | Tennessee | L | 56 | 86 | 6-4 | 0-0 | 11,084 | Knoxville | Tenn. | Thompson-Boling Arena | |||
| 12/20/2009 | A | Kentucky | L | 67 | 101 | 6-5 | 0-0 | 7,323 | Lexington | Ky. | Memorial Coliseum | |||
| 12/22/2009 | A | New Hampshire | W | 76 | 67 | 7-5 | 0-0 | 763 | Lundholm Gym | |||||
| 12/29/2009 | H | IPFW | W | 91 | 62 | 8-5 | 0-0 | 6,015 | Louisville | Ky. | Freedom Hall | |||
| 01/02/2010 | A | Cincinnati | W | 63 | 49 | 9-5 | 1-0 | 514 | Cincinnati | Ohio | Fifth Third Arena | |||
| 01/05/2010 | A | DePaul | L | 70 | 76 | OT | 9-6 | 1-1 | 2,254 | |||||
| 01/09/2010 | H | Providence | W | 67 | 48 | 10-6 | 2-1 | 6,021 | Louisville | Ky. | Freedom Hall | |||
| 01/16/2010 | A | 18 | Georgetown | L | 56 | 60 | 10-7 | 2-2 | 1,517 | Washington | D.C. | McDonough Arena | ||
| 01/19/2010 | H | 4 | Notre Dame | L | 60 | 78 | 10-8 | 2-3 | 6,324 | Louisville | Ky. | Freedom Hall | ||
| 01/23/2010 | H | Syracuse | L | 58 | 64 | 10-9 | 2-4 | 6,211 | Louisville | Ky. | Freedom Hall | |||
| 01/26/2010 | H | Villanova | W | 53 | 50 | 11-9 | 3-4 | 5,821 | Louisville | Ky. | Freedom Hall | |||
| 01/30/2010 | A | 16 | West Virginia | L | 66 | 72 | 11-10 | 3-5 | 3,788 | Morgantown | W.Va. | WVU Coliseum | ||
| 02/02/2010 | H | Cincinnati | L | 68 | 74 | OT | 11-11 | 3-6 | 5,981 | Louisville | Ky. | Freedom Hall | ||
| 02/07/2010 | H | 1 | Connecticut | L | 38 | 84 | 11-12 | 3-7 | 14,324 | Louisville | Ky. | Freedom Hall | ||
| 02/10/2010 | A | 24 | St. John's | L | 56 | 91 | 11-13 | 3-8 | 211 | |||||
| 02/14/2010 | A | Pittsburgh | L | 69 | 72 | 11-14 | 3-9 | 4,168 | Pittsburgh | Pa. | Petersen Events Center | |||
| 02/16/2010 | H | Marquette | W | 77 | 61 | 12-14 | 4-9 | 6,012 | Louisville | Ky. | Freedom Hall | |||
| 02/24/2010 | A | Seton Hall | W | 72 | 49 | 13-14 | 5-9 | 219 | ||||||
| 02/27/2010 | H | South Florida | L | 60 | 63 | 13-15 | 5-10 | 6,432 | Louisville | Ky. | Freedom Hall | |||
| 03/01/2010 | A | Rutgers | L | 52 | 72 | 13-16 | 5-11 | 3,250 | Louis Brown Ath. Ctr. Piscataway | N.J. | ||||
| 03/05/2010 | N | Pittsburgh | W | 79 | 71 | 14-16 | 5-11 | 2,010 | XL Center Hartford | Conn. | 2010 BIG EAST Tournament | |||
| 03/06/2010 | N | 3 | Notre Dame | L | 52 | 89 | 14-17 | 5-11 | 2,010 | XL Center Hartford | Conn. | 2010 BIG EAST Tournament | ||
| 03/17/2010 | H | Bradley | L | 59 | 69 | 14-18 | 5-11 | 691 | Louisville | Ky. | Freedom Hall | 2010 Women's Basketball Invitational |