Head Coach: Tom Collen Record: 20-10 (11-3 C-USA)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/05/2003 | H | OGBM Legends (Exhibition) | W | 91 | 61 | Louisville | Ky. | Cardinal Arena | ||||||
| 11/11/2003 | H | Indiana Lady Stars (Exhibition) | W | 78 | 53 | |||||||||
| 11/21/2003 | H | Xavier | L | 64 | 72 | 0-1 | 0-0 | 886 | Louisville | Ky. | Cardinal Arena | |||
| 11/23/2003 | H | IPFW | W | 81 | 70 | 1-1 | 0-0 | 474 | Louisville | Ky. | Freedom Hall | |||
| 11/25/2003 | A | Chattanooga | L | 65 | 68 | 1-2 | 0-0 | 1,022 | Chattanooga | Tenn. | McKenzie Arena | |||
| 11/28/2003 | N | Princeton | W | 68 | 61 | 2-2 | 0-0 | 321 | Nashville | Tenn. | Memorial Gym | 2003 Vanderbilt Tournament | ||
| 11/29/2003 | A | Vanderbilt | L | 68 | 73 | OT | 2-3 | 0-0 | 1,273 | Nashville | Tenn. | Memorial Gym | ||
| 12/03/2003 | A | Kentucky | L | 80 | 84 | OT | 2-4 | 0-0 | Lexington | Ky. | ||||
| 12/06/2003 | H | Western Kentucky | W | 76 | 75 | 3-4 | 0-0 | 1,025 | Louisville | Ky. | Freedom Hall | |||
| 12/09/2003 | A | Ball State | W | 94 | 86 | 4-4 | 0-0 | 733 | Worthen Arena - Muncie | Ind. | ||||
| 12/14/2003 | H | Jackson State | W | 76 | 48 | 5-4 | 0-0 | 741 | Louisville | Ky. | Freedom Hall | |||
| 12/18/2003 | A | Cleveland State | L | 68 | 79 | 5-5 | 0-0 | 104 | Goodman Arena -- Cleveland | Ohio | ||||
| 12/20/2003 | A | Detroit Mercy | W | 64 | 40 | 6-5 | 0-0 | 218 | ||||||
| 12/28/2003 | H | Florida Atlantic | W | 93 | 67 | 7-5 | 0-0 | 1,354 | Louisville | Ky. | Freedom Hall | |||
| 01/03/2004 | H | Morehead State | W | 61 | 39 | 8-5 | 0-0 | 1,534 | Louisville | Ky. | Freedom Hall | |||
| 01/09/2004 | A | DePaul | L | 83 | 102 | 8-6 | 0-1 | 2,068 | DePaul Athletic Center - Chicago | Ill. | ||||
| 01/11/2004 | A | Marquette | L | 58 | 72 | 8-7 | 0-2 | 1,221 | Milwaukee | Wis. | Al McGuire Center | |||
| 01/16/2004 | H | Saint Louis | W | 72 | 51 | 9-7 | 1-2 | 1,845 | Louisville | Ky. | Freedom Hall | |||
| 01/18/2004 | H | Memphis | W | 66 | 65 | 10-7 | 2-2 | 1,105 | Louisville | Ky. | Freedom Hall | |||
| 01/23/2004 | A | 21 | Texas Christian | L | 42 | 67 | 10-8 | 2-3 | 2,955 | Fort Worth | Texas | Daniel-Meyer Coliseum | ||
| 01/25/2004 | A | 23 | Houston | W | 77 | 75 | OT | 11-8 | 3-3 | 1,617 | Hofheinz Pavilion | |||
| 01/31/2004 | H | Cincinnati | W | 65 | 54 | 12-8 | 4-3 | 1,653 | Louisville | Ky. | Freedom Hall | |||
| 02/06/2004 | H | Alabama-Birmingham | W | 83 | 70 | 13-8 | 5-3 | 848 | Louisville | Ky. | Freedom Hall | |||
| 02/08/2004 | H | South Florida | W | 86 | 71 | 14-8 | 6-3 | 1,107 | Louisville | Ky. | Freedom Hall | |||
| 02/13/2004 | A | Tulane | W | 48 | 47 | 15-8 | 7-3 | 591 | New Orleans | La. | Fogelman Arena | |||
| 02/15/2004 | A | Southern Mississippi | W | 67 | 58 | 16-8 | 8-3 | 781 | ||||||
| 02/20/2004 | H | Charlotte | W | 86 | 84 | 17-8 | 9-3 | 907 | Louisville | Ky. | Cardinal Arena | |||
| 02/22/2004 | H | East Carolina | W | 79 | 75 | OT | 18-8 | 10-3 | 954 | Louisville | Ky. | Cardinal Arena | ||
| 02/28/2004 | A | Cincinnati | W | 58 | 48 | 19-8 | 11-3 | 4,872 | ||||||
| 03/05/2004 | N | Memphis | W | 63 | 58 | 20-8 | 11-3 | 758 | Ft. Worth | Texas | Daniel-Meyer Coliseum | 2004 C-USA Tournament | ||
| 03/06/2004 | A | 15 | Texas Christian | L | 59 | 69 | 20-9 | 11-3 | 3,986 | Ft. Worth | Texas | Daniel-Meyer Coliseum | 2004 C-USA Tournament | |
| 03/18/2004 | H | Western Michigan | L | 61 | 63 | 20-10 | 11-3 | Louisville | Ky. | Cardinal Arena | 2004 WNIT |