Head Coach: Martin Clapp Record: 19-10 (14-2 C-USA)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/01/2000 | H | Reebok Lady Stars (Exhibition) | W | 94 | 83 | |||||||||
| 11/08/2000 | H | Finland (Exhibition) | W | 81 | 37 | |||||||||
| 11/17/2000 | N | 25 | UC Santa Barbara | L | 67 | 78 | 0-1 | 0-0 | 1,134 | Lincoln | Neb. | 2000 Time Warner Cable Classic | ||
| 11/19/2000 | N | Oakland | L | 71 | 76 | 0-2 | 0-0 | 575 | Bob Devaney Sports Center | 2000 Time Warner Cable Classic | ||||
| 11/25/2000 | N | 15 | Texas | L | 59 | 73 | 0-3 | 0-0 | 187 | Torneo Cancun de Basquetbol | 2000 Torneo Cancun de Basquetbol | |||
| 11/26/2000 | N | Minnesota | L | 64 | 68 | 0-4 | 0-0 | 156 | Torneo Cancun de Basquetbol | 2000 Torneo Cancun de Basquetbol | ||||
| 11/30/2000 | A | Western Kentucky | L | 79 | 86 | 0-5 | 0-0 | 2,300 | Bowling Green | Ky. | ||||
| 12/02/2000 | H | Illinois State | W | 87 | 59 | 1-5 | 0-0 | 454 | Freedom Hall | |||||
| 12/09/2000 | H | Kentucky | W | 63 | 57 | 2-5 | 0-0 | 6,413 | Freedom Hall | |||||
| 12/17/2000 | A | 23 | Arizona | L | 60 | 90 | 2-6 | 0-0 | 1,560 | McKale Center - Tucson | Ariz. | |||
| 12/20/2000 | H | Canisius | W | 88 | 69 | 3-6 | 0-0 | 358 | Freedom Hall | |||||
| 12/28/2000 | H | Niagara | W | 92 | 62 | 4-6 | 0-0 | 653 | Freedom Hall | 2000 Holiday Classic | ||||
| 12/29/2000 | H | Austin Peay | W | 91 | 68 | 5-6 | 0-0 | 546 | Freedom Hall | 2000 Holiday Classic | ||||
| 01/01/2001 | H | Cincinnati | W | 72 | 58 | 6-6 | 1-0 | 643 | Freedom Hall | |||||
| 01/05/2001 | H | South Florida | W | 69 | 64 | 7-6 | 2-0 | 814 | Freedom Hall | |||||
| 01/07/2001 | A | Houston | L | 63 | 85 | 7-7 | 2-1 | 904 | Houston | Texas | Hofheinz Pavillion | |||
| 01/12/2001 | A | DePaul | W | 99 | 97 | OT | 8-7 | 3-1 | 1,503 | |||||
| 01/14/2001 | A | Marquette | W | 76 | 61 | 9-7 | 4-1 | 1,190 | Milwaukee | Wis. | U.S. Cellular Arena | |||
| 01/19/2001 | H | Charlotte | W | 69 | 51 | 10-7 | 5-1 | 1,428 | Kentucky International Convention Center | |||||
| 01/21/2001 | H | Saint Louis | W | 71 | 67 | 11-7 | 6-1 | 2,013 | Freedom Hall | |||||
| 01/26/2001 | A | Tulane | W | 64 | 60 | 12-7 | 7-1 | 1,513 | Fogelman Arena | |||||
| 01/28/2001 | A | Southern Mississippi | W | 70 | 60 | 13-7 | 8-1 | 738 | Hattiesburg | Miss. | ||||
| 02/02/2001 | H | Memphis | W | 88 | 62 | 14-7 | 9-1 | 3,254 | Freedom Hall | |||||
| 02/04/2001 | H | Alabama-Birmingham | W | 72 | 63 | 15-7 | 10-1 | 1,621 | Kentucky Convention Center | |||||
| 02/08/2001 | H | Marquette | W | 79 | 74 | OT | 16-7 | 11-1 | 1,431 | Freedom Hall | ||||
| 02/11/2001 | H | DePaul | W | 66 | 54 | 17-7 | 12-1 | 2,153 | ||||||
| 02/16/2001 | A | Saint Louis | W | 61 | 44 | 18-7 | 13-1 | 1,012 | St. Louis | Mo. | Bauman-Eberhardt | |||
| 02/18/2001 | A | Charlotte | L | 52 | 58 | 18-8 | 13-2 | 761 | Halton Arena - Charlotte | N.C. | ||||
| 02/24/2001 | A | Cincinnati | W | 70 | 57 | 19-8 | 14-2 | 1,937 | Cincinnati | Ohio | ||||
| 03/03/2001 | N | DePaul | L | 57 | 78 | 19-9 | 14-2 | 2,001 | U.S. Cellular Arena - Milwaukee | Wis. | 2001 Conference USA Tournament | |||
| 03/16/2001 | A | Xavier | L | 52 | 80 | 19-10 | 14-2 | 6,802 | Cincinnati | Ohio | Cintas Center | 2001 NCAA Tournament First Round |