Head Coach: Jeff Walz Record: 36-3 (15-1 ACC)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | TV | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/10/2017 | H | Southeast Missouri State | W | 80 | 40 | ACC Network Extra | 1-0 | 0-0 | 6,054 | Louisville | Ky. | KFC Yum! Center | 2017 Women's NIT | ||
| 11/12/2017 | A | 5 | Ohio State | W | 95 | 90 | OT | ESPNU | 2-0 | 0-0 | 9,711 | Columbus | Ohio | Nationwide Arena | |
| 11/14/2017 | H | Toledo | W | 90 | 55 | ACC Network Extra | 3-0 | 0-0 | 5,444 | Louisville | Ky. | KFC Yum! Center | 2017 Women's NIT | ||
| 11/16/2017 | H | 24 | Michigan | W | 74 | 49 | ACC Network Extra | 4-0 | 0-0 | 5,651 | Louisville | Ky. | KFC Yum! Center | 2017 Women's NIT | |
| 11/19/2017 | H | 10 | Oregon | W | 74 | 61 | CBS Sports Network | 5-0 | 0-0 | 6,162 | Louisville | Ky. | KFC Yum! Center | 2017 Women's NIT | |
| 11/24/2017 | H | Murray State | W | 115 | 51 | ACC Network Extra | 6-0 | 0-0 | 6,881 | Louisville | Ky. | KFC Yum! Center | |||
| 11/30/2017 | A | Indiana | W | 72 | 59 | BTN | 7-0 | 0-0 | 2,853 | Simon Skjodt Assembly Hall | 2017 ACC/Big 10 Challenge | ||||
| 12/03/2017 | A | South Dakota State | W | 68 | 64 | 8-0 | 0-0 | 2,506 | |||||||
| 12/05/2017 | H | Tennessee-Martin | W | 91 | 56 | ACC Network Extra | 9-0 | 0-0 | 6,279 | Louisville | Ky. | KFC Yum! Center | |||
| 12/07/2017 | H | Vanderbilt | W | 79 | 57 | ACC Network Extra | 10-0 | 0-0 | 6,132 | Louisville | Ky. | KFC Yum! Center | |||
| 12/09/2017 | H | Middle Tennessee | W | 80 | 26 | ACC Network Extra | 11-0 | 0-0 | 6,752 | Louisville | Ky. | KFC Yum! Center | |||
| 12/12/2017 | H | Tennessee State | W | 95 | 56 | ACC Network Extra | 12-0 | 0-0 | 5,782 | Louisville | Ky. | KFC Yum! Center | |||
| 12/17/2017 | A | Kentucky | W | 87 | 63 | SECN | 13-0 | 0-0 | 5,871 | Lexington | Ky. | Memorial Coliseum | |||
| 12/20/2017 | A | Air Force | W | 62 | 50 | 14-0 | 0-0 | 537 | Clune Arena - USAF Academy | Colo. | |||||
| 12/28/2017 | A | Georgia Tech | W | 74 | 71 | ACC Network Extra | 15-0 | 1-0 | 1,473 | Atlanta | Ga. | McCamish Pavilion | |||
| 12/31/2017 | A | North Carolina State | W | 55 | 47 | Fox Sports Regional | 16-0 | 2-0 | 2,865 | ||||||
| 01/04/2018 | H | 17 | Duke | W | 66 | 60 | ACC Network Extra | 17-0 | 3-0 | 8,101 | Louisville | Ky. | KFC Yum! Center | ||
| 01/07/2018 | H | Virginia Tech | W | 67 | 56 | ACC Network Extra | 18-0 | 4-0 | 7,523 | Louisville | Ky. | KFC Yum! Center | |||
| 01/11/2018 | H | 2 | Notre Dame | W | 100 | 67 | ESPN | 19-0 | 5-0 | 12,614 | Louisville | Ky. | KFC Yum! Center | ||
| 01/18/2018 | A | Pittsburgh | W | 77 | 51 | ACC Network Extra | 20-0 | 6-0 | 441 | ||||||
| 01/21/2018 | H | 12 | Florida State | L | 49 | 50 | ESPN2 | 20-1 | 6-1 | 14,248 | Louisville | Ky. | KFC Yum! Center | ||
| 01/25/2018 | A | Miami, Fla. | W | 84 | 74 | ACC Network Extra | 21-1 | 7-1 | 2,706 | Watsco Center | Coral Gables | Fla. | ||||
| 01/28/2018 | H | Wake Forest | W | 89 | 52 | RSN | 22-1 | 8-1 | 10,139 | Louisville | Ky. | KFC Yum! Center | |||
| 02/01/2018 | A | Virginia | W | 77 | 41 | RSN | 23-1 | 9-1 | 2,877 | Charlottesville | Va. | JPJ Arena | |||
| 02/04/2018 | A | Syracuse | W | 84 | 77 | ACC Network Extra | 24-1 | 10-1 | 2,575 | ||||||
| 02/07/2018 | H | Clemson | W | 65 | 46 | ACC Network Extra | 25-1 | 11-1 | 7,014 | Louisville | Ky. | KFC Yum! Center | |||
| 02/12/2018 | A | 1 | Connecticut | L | 58 | 69 | ESPN2 | 25-2 | 11-1 | 10,167 | |||||
| 02/15/2018 | A | Boston College | W | 87 | 52 | ACC Network Extra | 26-2 | 12-1 | 929 | Chestnut Hill | Mass. | ||||
| 02/18/2018 | A | North Carolina | W | 67 | 57 | RSN | 27-2 | 13-1 | 3,934 | ||||||
| 02/22/2018 | H | Virginia | W | 51 | 39 | ACC Network Extra | 28-2 | 14-1 | 8,434 | Louisville | Ky. | KFC Yum! Center | |||
| 02/25/2018 | H | Pittsburgh | W | 81 | 49 | ACC Network Extra | 29-2 | 15-1 | 10,431 | Louisville | Ky. | KFC Yum! Center | |||
| 03/02/2018 | N | Virginia Tech | W | 73 | 70 | RSN | 30-2 | 15-1 | 3,297 | the Greensboro Coliseum - Greensboro | N.C. | 2018 ACC Tournament | |||
| 03/03/2018 | N | 23 | North Carolina State | W | 64 | 59 | ESPNU | 31-2 | 15-1 | the Greensboro Coliseum - Greensboro | N.C. | 2018 ACC Tournament | |||
| 03/04/2018 | N | 5 | Notre Dame | W | 74 | 72 | ESPN2 | 32-2 | 15-1 | 7,424 | the Greensboro Coliseum - Greensboro | N.C. | 2018 ACC Tournament | ||
| 03/16/2018 | H | Boise State | W | 74 | 42 | ESPN2 | 33-2 | 15-1 | Louisville | Ky. | KFC Yum! Center | 2018 NCAA Tournament First Round | |||
| 03/18/2018 | H | Marquette | W | 90 | 72 | ESPN2 | 34-2 | 15-1 | 8,017 | Louisville | Ky. | KFC Yum! Center | 2018 NCAA Tournament Second Round | ||
| 03/23/2018 | N | 15 | Stanford | W | 86 | 59 | ESPN | 35-2 | 15-1 | 5,715 | Lexington | Ky. | Rupp Arena | 2018 NCAA Tournament Sweet Sixteen | |
| 03/25/2018 | N | 13 | Oregon State | W | 76 | 43 | ESPN | 36-2 | 15-1 | 6,268 | Lexington | Ky. | Rupp Arena | 2018 NCAA Tournament Elite Eight | |
| 03/30/2018 | N | 4 | Mississippi State | L | 63 | 73 | OT | ESPN2 | 36-3 | 15-1 | Columbus | Ohio | Nationwide Arena | 2018 NCAA Tournament Final Four |