Head Coach: Jeff Walz Record: 26-10 (10-6 Big East)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/30/2007 | H | Indiana All-Stars (Exhibition) | W | 84 | 50 | ||||||||
| 11/03/2007 | H | All-Star Girls Report (Exhibition) | W | 98 | 85 | ||||||||
| 11/10/2007 | A | Ball State | W | 81 | 62 | 1-0 | 0-0 | 1,953 | |||||
| 11/17/2007 | N | Western Carolina | L | 72 | 77 | 1-1 | 0-0 | 4,109 | Minneapolis | Minn. | Williams Arena | 2007 Subway Classic | |
| 11/18/2007 | A | Minnesota | L | 69 | 74 | 1-2 | 0-0 | 5,723 | Minneapolis | Minn. | Williams Arena | 2007 Subway Classic | |
| 11/23/2007 | N | Delaware | W | 80 | 55 | 2-2 | 0-0 | 1,403 | Chattanooga | Tenn. | The McKenzie Arena | 2007 Panera Bread Classic | |
| 11/24/2007 | A | Chattanooga | W | 80 | 53 | 3-2 | 0-0 | 1,324 | Chattanooga | Tenn. | The McKenzie Arena | 2007 Panera Bread Classic | |
| 12/02/2007 | H | Florida | W | 79 | 62 | 4-2 | 0-0 | 3,241 | Louisville | Ky. | Freedom Hall | ||
| 12/09/2007 | H | Xavier | W | 67 | 45 | 5-2 | 0-0 | 5,123 | Louisville | Ky. | Freedom Hall | ||
| 12/12/2007 | A | Vermont | W | 87 | 52 | 6-2 | 0-0 | 817 | Burlington | Vt. | Patrick Gymnasium | ||
| 12/16/2007 | A | Western Kentucky | W | 76 | 60 | 7-2 | 0-0 | 3,164 | Bowling Green | Ky. | E.A. Diddle Arena | ||
| 12/20/2007 | A | Kentucky | W | 80 | 65 | 8-2 | 0-0 | 7,887 | Lexington | Ky. | Rupp Arena | ||
| 12/22/2007 | A | Coppin State | W | 69 | 51 | 9-2 | 0-0 | 268 | Baltimore | Md. | Coppin Center | ||
| 12/28/2007 | H | Mercer | W | 99 | 74 | 10-2 | 0-0 | 5,123 | Louisville | Ky. | Freedom Hall | ||
| 12/30/2007 | H | Middle Tennessee | W | 76 | 64 | 11-2 | 0-0 | 5,243 | Louisville | Ky. | Freedom Hall | ||
| 01/05/2008 | A | Syracuse | L | 56 | 79 | 11-3 | 0-1 | 1,152 | Syracuse | N.Y. | Carrier Dome | ||
| 01/08/2008 | H | 14 | Notre Dame | L | 74 | 82 | 11-4 | 0-2 | 5,243 | Louisville | Ky. | Freedom Hall | |
| 01/12/2008 | H | 1 | Connecticut | L | 71 | 92 | 11-5 | 0-3 | 19,123 | Louisville | Ky. | Freedom Hall | |
| 01/15/2008 | H | Cincinnati | W | 69 | 37 | 12-5 | 1-3 | 5,023 | Louisville | Ky. | Freedom Hall | ||
| 01/20/2008 | A | 5 | Rutgers | L | 57 | 70 | 12-6 | 1-4 | 5,081 | Piscataway | N.J. | Louis Brown Athletic Ctr | |
| 01/23/2008 | H | Marquette | W | 79 | 69 | 13-6 | 2-4 | 5,023 | Louisville | Ky. | Freedom Hall | ||
| 01/27/2008 | A | 19 | Pittsburgh | L | 67 | 76 | 13-7 | 2-5 | 8,509 | Pittsburgh | Pa. | Petersen Events Center | |
| 01/30/2008 | A | Cincinnati | W | 79 | 56 | 14-7 | 3-5 | 478 | Cincinnati | Ohio | Fifth Third Arena | ||
| 02/02/2008 | H | South Florida | W | 87 | 51 | 15-7 | 4-5 | 6,845 | Louisville | Ky. | Freedom Hall | ||
| 02/10/2008 | A | 25 | DePaul | W | 79 | 68 | 16-7 | 5-5 | 3,022 | McGrath Arena - Chicago | Ill. | ||
| 02/13/2008 | A | St. John's | W | 96 | 74 | 17-7 | 6-5 | 525 | Carnesecca Arena | ||||
| 02/17/2008 | H | Georgetown | W | 65 | 51 | 18-7 | 7-5 | 6,125 | Louisville | Ky. | Freedom Hall | ||
| 02/23/2008 | A | Seton Hall | W | 84 | 48 | 19-7 | 8-5 | 240 | South Orange | N.J. | |||
| 02/26/2008 | H | Providence | W | 82 | 57 | 20-7 | 9-5 | 5,023 | Louisville | Ky. | Freedom Hall | ||
| 03/01/2008 | A | 13 | West Virginia | L | 70 | 78 | 20-8 | 9-6 | 4,157 | Morgantown | W.Va. | WVU Coliseum | |
| 03/03/2008 | H | Villanova | W | 84 | 52 | 21-8 | 10-6 | 6,345 | Louisville | Ky. | Freedom Hall | ||
| 03/08/2008 | N | St. John's | W | 63 | 47 | 22-8 | 10-6 | 8,292 | XL Center Hartford | Conn. | 2008 BIG EAST Tournament | ||
| 03/09/2008 | N | 4 | Rutgers | W | 57 | 56 | 23-8 | 10-6 | 8,336 | XL Center Hartford | Conn. | 2008 BIG EAST Tournament | |
| 03/10/2008 | N | 13 | West Virginia | W | 67 | 60 | 24-8 | 10-6 | 9,302 | XL Center Hartford | Conn. | 2008 BIG EAST Tournament | |
| 03/11/2008 | N | 1 | Connecticut | L | 59 | 65 | 24-9 | 10-6 | 9,982 | XL Center Hartford | Conn. | 2008 BIG EAST Tournament | |
| 03/23/2008 | N | Miami, Ohio | W | 81 | 67 | 25-9 | 10-6 | 6,556 | 2008 NCAA Tournament First Round | ||||
| 03/25/2008 | N | 15 | Kansas State | W | 80 | 63 | 26-9 | 10-6 | 6,834 | 2008 NCAA Tournament Second Round | |||
| 03/29/2008 | N | 2 | North Carolina | L | 74 | 78 | 26-10 | 10-6 | 4,181 | New Orleans (New Orleans Arena | 2008 NCAA Tournament Sweet Sixteen |