Head Coach: Martin Clapp and Sara White Record: 16-13 (9-7 C-USA)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | Overall | Conf | Event |
|---|---|---|---|---|---|---|---|---|---|
| 11/20/1999 | H | UNC Asheville | W | 79 | 56 | 1-0 | 0-0 | ||
| 11/23/1999 | A | Alaska-Anchorage | W | 69 | 58 | 2-0 | 0-0 | 1999 Great Alaska Shootout | |
| 11/25/1999 | N | 16 | Kansas | L | 68 | 78 | 2-1 | 0-0 | 1999 Great Alaska Shootout |
| 11/30/1999 | A | Arkansas State | L | 70 | 84 | 2-2 | 0-0 | ||
| 12/04/1999 | H | Maryland-Eastern Shore | W | 99 | 59 | 3-2 | 0-0 | ||
| 12/11/1999 | H | East Tennessee State | W | 63 | 47 | 4-2 | 0-0 | ||
| 12/16/1999 | H | Bellarmine | W | 80 | 56 | 5-2 | 0-0 | ||
| 12/18/1999 | A | Virginia Commonwealth | L | 60 | 76 | 5-3 | 0-0 | ||
| 12/21/1999 | A | Butler | W | 82 | 50 | 6-3 | 0-0 | ||
| 12/28/1999 | H | Western Illinois | W | 55 | 51 | 7-3 | 0-0 | 1999 adidas Seelbach Hilton Holiday Classic | |
| 12/29/1999 | H | 15 | Arizona | L | 70 | 80 | 7-4 | 0-0 | 1999 adidas Seelbach Hilton Holiday Classic |
| 01/02/2000 | H | Cincinnati | W | 65 | 56 | 8-4 | 1-0 | ||
| 01/07/2000 | A | Marquette | L | 57 | 67 | 8-5 | 1-1 | ||
| 01/09/2000 | A | DePaul | L | 61 | 84 | 8-6 | 1-2 | ||
| 01/14/2000 | H | Southern Mississippi | W | 83 | 52 | 9-6 | 2-2 | ||
| 01/16/2000 | H | 13 | Tulane | W | 75 | 73 | 10-6 | 3-2 | |
| 01/20/2000 | H | Saint Louis | W | 66 | 58 | 11-6 | 4-2 | ||
| 01/22/2000 | H | Charlotte | W | 70 | 63 | 12-6 | 5-2 | ||
| 01/28/2000 | A | Alabama-Birmingham | W | 67 | 50 | 13-6 | 6-2 | ||
| 01/30/2000 | A | Memphis | L | 58 | 61 | 13-7 | 6-3 | ||
| 02/05/2000 | A | Charlotte | W | 70 | 63 | 14-7 | 7-3 | ||
| 02/07/2000 | A | Saint Louis | L | 52 | 56 | 14-8 | 7-4 | ||
| 02/11/2000 | H | DePaul | L | 67 | 81 | 14-9 | 7-5 | ||
| 02/13/2000 | H | Marquette | L | 49 | 60 | 14-10 | 7-6 | ||
| 02/18/2000 | A | South Florida | W | 58 | 43 | 15-10 | 8-6 | ||
| 02/20/2000 | H | Houston | W | 68 | 54 | 16-10 | 9-6 | ||
| 02/22/2000 | A | Kentucky | L | 65 | 75 | 16-11 | 9-6 | ||
| 02/27/2000 | A | Cincinnati | L | 65 | 84 | 16-12 | 9-7 | ||
| 03/03/2000 | H | Charlotte | L | 62 | 75 | 16-13 | 9-7 | 2000 Conference USA Tournament |