Head Coach: Martin Clapp and Sara White Record: 20-12 (12-4 C-USA)
| Date | Site | Opp AP | Opponent | W/L | UL | Opp | OT | Overall | Conf | Event |
|---|---|---|---|---|---|---|---|---|---|---|
| 11/14/1997 | A | 17 | Western Kentucky | L | 73 | 89 | 0-1 | 0-0 | 1997 Preseason Women's NIT | |
| 11/26/1997 | A | Wright State | W | 86 | 73 | 1-1 | 0-0 | |||
| 11/29/1997 | N | Penn State | W | 67 | 58 | 2-1 | 0-0 | 1997 Dial Classic | ||
| 11/30/1997 | A | 2 | Old Dominion | L | 39 | 77 | 2-2 | 0-0 | 1997 Dial Classic | |
| 12/04/1997 | H | 20 | Arkansas | L | 57 | 69 | 2-3 | 0-0 | ||
| 12/09/1997 | A | Butler | L | 58 | 69 | 2-4 | 0-0 | |||
| 12/18/1997 | A | Bradley | L | 67 | 76 | 2-5 | 0-0 | |||
| 12/21/1997 | H | Arkansas State | W | 93 | 80 | 3-5 | 0-0 | |||
| 12/27/1997 | N | Monmouth | W | 89 | 44 | 4-5 | 0-0 | 1997 Florida International Holiday Classic | ||
| 12/28/1997 | A | 24 | Florida International | L | 60 | 77 | 4-6 | 0-0 | 1997 Florida International Holiday Classic | |
| 01/02/1998 | H | DePaul | W | 91 | 80 | 5-6 | 1-0 | 1998 Games Played at Louisville Gardens | ||
| 01/04/1998 | H | Marquette | L | 59 | 79 | 5-7 | 1-1 | 1998 Games Played at Louisville Gardens | ||
| 01/09/1998 | A | South Florida | W | 83 | 70 | OT | 6-7 | 2-1 | ||
| 01/11/1998 | A | Houston | W | 79 | 67 | 7-7 | 3-1 | |||
| 01/16/1998 | A | Saint Louis | L | 63 | 64 | 7-8 | 3-2 | |||
| 01/18/1998 | A | Charlotte | W | 71 | 60 | 8-8 | 4-2 | |||
| 01/21/1998 | A | Kentucky | W | 80 | 62 | 9-8 | 4-2 | 1998 Game was an away game for Louisville played at Freedom Hall | ||
| 01/23/1998 | H | Memphis | L | 84 | 86 | 9-9 | 4-3 | 1998 Games Played at Louisville Gardens | ||
| 01/25/1998 | A | Alabama-Birmingham | W | 68 | 67 | 10-9 | 5-3 | |||
| 01/31/1998 | H | Tulane | W | 81 | 66 | 11-9 | 6-3 | |||
| 02/02/1998 | H | Southern Mississippi | W | 85 | 68 | 12-9 | 7-3 | |||
| 02/06/1998 | A | DePaul | W | 69 | 52 | 13-9 | 8-3 | |||
| 02/08/1998 | A | Marquette | W | 79 | 74 | 14-9 | 9-3 | |||
| 02/12/1998 | A | Cincinnati | L | 61 | 70 | 14-10 | 9-4 | |||
| 02/16/1998 | H | Cincinnati | W | 67 | 54 | 15-10 | 10-4 | |||
| 02/20/1998 | H | Charlotte | W | 73 | 50 | 16-10 | 11-4 | |||
| 02/22/1998 | H | Saint Louis | W | 62 | 61 | 17-10 | 12-4 | |||
| 02/28/1998 | H | Alabama-Birmingham | W | 90 | 44 | 18-10 | 12-4 | 1998 Conference USA Tournament | ||
| 03/01/1998 | H | Marquette | W | 77 | 66 | 19-10 | 12-4 | 1998 Conference USA Tournament | ||
| 03/02/1998 | H | Memphis | L | 75 | 79 | 19-11 | 12-4 | 1998 Conference USA Tournament | ||
| 03/14/1998 | N | Utah | W | 69 | 61 | 20-11 | 12-4 | 1998 NCAA Tournament First Round | ||
| 03/16/1998 | N | Duke | L | 53 | 69 | 20-12 | 12-4 | 1998 NCAA Tournament Second Round |