Head Coach: Bud Childers Record: 24-11 (9-5 Metro)
| Date | Site | Opponent | W/L | UL | Opp | OT | Overall | Conf | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/24/1990 | N | Duke | W | 73 | 66 | 1-0 | 0-0 | 1990 Felpausch Classic | ||||
| 11/25/1990 | A | Michigan State | L | 73 | 82 | 1-1 | 0-0 | 1990 Felpausch Classic | ||||
| 11/27/1990 | A | Detroit Mercy | W | 84 | 72 | 2-1 | 0-0 | 1990 Felpausch Classic | ||||
| 12/01/1990 | H | Eastern Michigan | W | 84 | 72 | 3-1 | 0-0 | Louisville | Ky. | Commonwealth Convention Center | 1990 Seelbach Classic | |
| 12/02/1990 | H | Colorado State | W | 75 | 65 | 4-1 | 0-0 | Louisville | Ky. | Commonwealth Convention Center | 1990 Seelbach Classic | |
| 12/06/1990 | H | Eastern Illinois | W | 78 | 71 | 5-1 | 0-0 | Louisville | Ky. | Commonwealth Convention Center | ||
| 12/09/1990 | H | Bradley | W | 82 | 77 | 6-1 | 0-0 | Louisville | Ky. | Commonwealth Convention Center | ||
| 12/15/1990 | A | Eastern Kentucky | L | 68 | 71 | 6-2 | 0-0 | |||||
| 12/20/1990 | H | Indiana State | W | 92 | 86 | OT | 7-2 | 0-0 | Louisville | Ky. | Commonwealth Convention Center | |
| 12/29/1990 | H | Saint Louis | W | 92 | 50 | 8-2 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 01/02/1991 | A | Evansville | W | 71 | 64 | 9-2 | 0-0 | |||||
| 01/05/1991 | H | Tulane | W | 76 | 43 | 10-2 | 1-0 | Louisville | Ky. | Commonwealth Convention Center | ||
| 01/07/1991 | H | Southern Mississippi | W | 80 | 71 | 11-2 | 2-0 | Louisville | Ky. | Freedom Hall | ||
| 01/12/1991 | A | South Carolina | L | 67 | 75 | 11-3 | 2-1 | |||||
| 01/14/1991 | A | Florida State | L | 70 | 83 | 11-4 | 2-2 | |||||
| 01/17/1991 | H | Kentucky | W | 70 | 63 | 12-4 | 2-2 | Louisville | Ky. | Cardinal Arena | ||
| 01/19/1991 | H | Cincinnati | W | 81 | 56 | 13-4 | 3-2 | Louisville | Ky. | Freedom Hall | ||
| 01/21/1991 | A | Memphis | W | 96 | 83 | 14-4 | 4-2 | |||||
| 01/26/1991 | H | Memphis | W | 92 | 83 | 15-4 | 5-2 | Louisville | Ky. | Freedom Hall | ||
| 01/28/1991 | H | Virginia Tech | W | 78 | 61 | 16-4 | 6-2 | Louisville | Ky. | Cardinal Arena | ||
| 02/02/1991 | A | Tulane | W | 78 | 62 | 17-4 | 7-2 | |||||
| 02/04/1991 | A | Southern Mississippi | L | 67 | 78 | 17-5 | 7-3 | |||||
| 02/09/1991 | H | South Carolina | L | 62 | 66 | 17-6 | 7-4 | Louisville | Ky. | Cardinal Arena | ||
| 02/11/1991 | H | Florida State | L | 52 | 86 | 17-7 | 7-5 | Louisville | Ky. | Cardinal Arena | ||
| 02/14/1991 | H | Austin Peay | W | 92 | 64 | 18-7 | 7-5 | Louisville | Ky. | Cardinal Arena | ||
| 02/18/1991 | A | Cincinnati | W | 90 | 46 | 19-7 | 8-5 | |||||
| 02/22/1991 | N | Northern Arizona | W | 98 | 58 | 20-7 | 8-5 | 1991 Northern Lights Invitational | ||||
| 02/23/1991 | N | Appalachian State | W | 109 | 61 | 21-7 | 8-5 | 1991 Northern Lights Invitational | ||||
| 02/24/1991 | N | Northern Illinois | L | 60 | 63 | 21-8 | 8-5 | 1991 Northern Lights Invitational | ||||
| 02/27/1991 | A | Virginia Tech | W | 70 | 57 | 22-8 | 9-5 | |||||
| 03/04/1991 | H | Memphis | W | 85 | 75 | 23-8 | 9-5 | Louisville | Ky. | Commonwealth Convention Center | 1991 Metro Tournament | |
| 03/05/1991 | H | Florida State | L | 70 | 83 | 23-9 | 9-5 | Louisville | Ky. | Commonwealth Convention Center | 1991 Metro Tournament | |
| 03/21/1991 | N | Kansas | L | 66 | 71 | 23-10 | 9-5 | 1991 WNIT | ||||
| 03/22/1991 | N | Notre Dame | W | 80 | 75 | 24-10 | 9-5 | 1991 WNIT | ||||
| 03/23/1991 | N | Alabama-Birmingham | L | 75 | 81 | 24-11 | 9-5 | 1991 WNIT |