Head Coach: Peggy Fiehrer Record: 4-24 (0-12 Metro)
| Date | Site | Opponent | W/L | UL | Opp | OT | Overall | Conf | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/26/1988 | H | Northern Kentucky | W | 68 | 61 | 1-0 | 0-0 | Louisville | Ky. | Ballard High School | ||
| 11/28/1988 | A | Eastern Kentucky | L | 55 | 68 | 1-1 | 0-0 | |||||
| 12/02/1988 | A | Louisiana Tech | L | 47 | 77 | 1-2 | 0-0 | 1988 Dial Lady Techster Classic | ||||
| 12/03/1988 | N | Oklahoma State | L | 64 | 86 | 1-3 | 0-0 | 1988 Dial Lady Techster Classic | ||||
| 12/06/1988 | H | Marshall | W | 64 | 58 | 2-3 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 12/10/1988 | A | Dayton | L | 49 | 59 | 2-4 | 0-0 | |||||
| 12/13/1988 | H | Morehead State | L | 69 | 72 | 2-5 | 0-0 | Louisville | Ky. | Manual High School | ||
| 12/16/1988 | A | Indiana | L | 57 | 64 | 2-6 | 0-0 | |||||
| 12/19/1988 | A | Wright State | W | 65 | 53 | 3-6 | 0-0 | |||||
| 01/02/1989 | A | Evansville | L | 65 | 68 | 3-7 | 0-0 | |||||
| 01/04/1989 | H | Vanderbilt | L | 68 | 76 | 3-8 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 01/07/1989 | A | Maine | L | 55 | 56 | 3-9 | 0-0 | |||||
| 01/11/1989 | H | Miami, Fla. | L | 58 | 59 | 3-10 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 01/14/1989 | H | South Carolina | L | 74 | 81 | 3-11 | 0-1 | Louisville | Ky. | Manual High School | ||
| 01/16/1989 | H | Florida State | L | 65 | 66 | 3-12 | 0-2 | Louisville | Ky. | Manual High School | ||
| 01/18/1989 | H | Kentucky | L | 73 | 77 | 3-13 | 0-2 | Louisville | Ky. | Bellarmine College | ||
| 01/23/1989 | A | Cincinnati | L | 46 | 48 | 3-14 | 0-3 | |||||
| 01/28/1989 | A | Memphis | L | 55 | 82 | 3-15 | 0-4 | |||||
| 01/30/1989 | A | Southern Mississippi | L | 57 | 82 | 3-16 | 0-5 | |||||
| 02/04/1989 | H | Virginia Tech | L | 62 | 73 | 3-17 | 0-6 | Louisville | Ky. | Manual High School | ||
| 02/06/1989 | H | Austin Peay | W | 75 | 64 | 4-17 | 0-6 | Louisville | Ky. | Freedom Hall | ||
| 02/13/1989 | A | Florida State | L | 76 | 82 | 4-18 | 0-7 | |||||
| 02/18/1989 | A | South Carolina | L | 59 | 89 | 4-19 | 0-8 | |||||
| 02/22/1989 | H | Cincinnati | L | 45 | 59 | 4-20 | 0-9 | Louisville | Ky. | Freedom Hall | ||
| 02/25/1989 | H | Memphis | L | 76 | 80 | OT | 4-21 | 0-10 | Louisville | Ky. | Manual High School | |
| 02/27/1989 | H | Southern Mississippi | L | 78 | 81 | 4-22 | 0-11 | Louisville | Ky. | Manual High School | ||
| 03/04/1989 | A | Virginia Tech | L | 57 | 65 | 4-23 | 0-12 | |||||
| 03/09/1989 | N | Southern Mississippi | L | 62 | 94 | 4-24 | 0-12 | 1989 Metro Tournament |