Head Coach: Peggy Fiehrer Record: 12-16 (4-8 Metro)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/26/1987 | A | Kentucky | L | 78 | 98 | 0-1 | 0-0 | 1987 Lady Kat Tournament | |||
| 11/27/1987 | N | Central Michigan | W | 72 | 62 | 1-1 | 0-0 | 1987 Lady Kat Tournament | |||
| 12/01/1987 | A | Purdue | L | 54 | 66 | 1-2 | 0-0 | ||||
| 12/04/1987 | N | Northwestern | W | 61 | 51 | 2-2 | 0-0 | 1987 Northwestern Tournament | |||
| 12/05/1987 | N | James Madison | L | 38 | 60 | 2-3 | 0-0 | 1987 Northwestern Tournament | |||
| 12/09/1987 | H | Evansville | W | 83 | 80 | 3-3 | 0-0 | Louisville | Ky. | Manual High School | |
| 12/12/1987 | H | Miami, Ohio | W | 88 | 55 | 4-3 | 0-0 | Louisville | Ky. | Manual High School | |
| 12/17/1987 | A | Morehead State | L | 59 | 60 | 4-4 | 0-0 | ||||
| 12/19/1987 | A | Marshall | L | 64 | 78 | 4-5 | 0-0 | ||||
| 12/21/1987 | H | Wright State | W | 78 | 60 | 5-5 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 01/02/1988 | H | Dayton | W | 77 | 59 | 6-5 | 0-0 | Louisville | Ky. | Manual High School | |
| 01/04/1988 | H | Indiana | W | 55 | 48 | 7-5 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 01/13/1988 | H | South Carolina | L | 55 | 57 | 7-6 | 0-1 | Louisville | Ky. | Manual High School | |
| 01/16/1988 | A | Virginia Tech | L | 67 | 68 | 7-7 | 0-2 | ||||
| 01/23/1988 | A | Vanderbilt | L | 56 | 102 | 7-8 | 0-2 | ||||
| 01/25/1988 | A | Cincinnati | L | 55 | 60 | 7-9 | 0-3 | ||||
| 01/28/1988 | H | Eastern Kentucky | W | 108 | 88 | 8-9 | 0-3 | Louisville | Ky. | Manual High School | |
| 01/30/1988 | H | Southern Mississippi | W | 89 | 84 | 9-9 | 1-3 | Louisville | Ky. | Manual High School | |
| 02/01/1988 | H | Memphis | L | 66 | 82 | 9-10 | 1-4 | Louisville | Ky. | Freedom Hall | |
| 02/06/1988 | A | South Carolina | L | 45 | 55 | 9-11 | 1-5 | ||||
| 02/08/1988 | A | Florida State | L | 65 | 99 | 9-12 | 1-6 | ||||
| 02/15/1988 | H | Virginia Tech | L | 59 | 62 | 9-13 | 1-7 | Louisville | Ky. | Freedom Hall | |
| 02/17/1988 | H | Cincinnati | W | 62 | 60 | 10-13 | 2-7 | Louisville | Ky. | Manual High School | |
| 02/20/1988 | A | DePaul | L | 52 | 84 | 10-14 | 2-7 | ||||
| 02/27/1988 | A | Southern Mississippi | W | 53 | 52 | 11-14 | 3-7 | ||||
| 02/29/1988 | A | Memphis | W | 76 | 73 | 12-14 | 4-7 | ||||
| 03/03/1988 | H | Florida State | L | 70 | 73 | 12-15 | 4-8 | Louisville | Ky. | Manual High School | |
| 03/10/1988 | N | Memphis | L | 53 | 73 | 12-16 | 4-8 | 1988 Metro Tournament |