Head Coach: Peggy Fiehrer Record: 8-20 (2-8 Metro)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/23/1985 | A | Northern Kentucky | W | 68 | 62 | 1-0 | 0-0 | ||||
| 11/26/1985 | A | Kentucky State | W | 93 | 48 | 2-0 | 0-0 | ||||
| 12/02/1985 | A | DePaul | L | 54 | 64 | 2-1 | 0-0 | ||||
| 12/07/1985 | H | Purdue | L | 72 | 81 | 2-2 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 12/10/1985 | H | Eastern Kentucky | W | 83 | 63 | 3-2 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 12/14/1985 | A | Miami, Ohio | L | 64 | 75 | 3-3 | 0-0 | ||||
| 12/18/1985 | H | Indiana | L | 53 | 68 | 3-4 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 12/27/1985 | A | North Carolina State | L | 53 | 72 | 3-5 | 0-0 | 1985 NC State Christmas Tourney | |||
| 12/28/1985 | N | Boston College | L | 68 | 74 | 3-6 | 0-0 | 1985 NC State Christmas Tourney | |||
| 01/04/1986 | H | Southern Mississippi | W | 54 | 53 | 4-6 | 1-0 | Louisville | Ky. | Freedom Hall | |
| 01/06/1986 | H | Tulane | L | 61 | 64 | 4-7 | 1-1 | Louisville | Ky. | Freedom Hall | |
| 01/08/1986 | A | Tennessee State | W | 75 | 62 | 5-7 | 1-1 | ||||
| 01/11/1986 | A | Florida State | L | 64 | 67 | 5-8 | 1-2 | ||||
| 01/16/1986 | H | Western Kentucky | L | 55 | 98 | 5-9 | 1-2 | Louisville | Ky. | Broadbent Arena | |
| 01/18/1986 | A | Memphis | L | 65 | 83 | 5-10 | 1-3 | ||||
| 01/22/1986 | A | IUPUI | W | 76 | 61 | 6-10 | 1-3 | ||||
| 01/25/1986 | A | Virginia Tech | L | 75 | 89 | 6-11 | 1-4 | ||||
| 01/27/1986 | A | South Carolina | L | 77 | 83 | 6-12 | 1-5 | ||||
| 01/30/1986 | A | Morehead State | W | 65 | 63 | 7-12 | 1-5 | ||||
| 02/01/1986 | A | Cincinnati | L | 65 | 81 | 7-13 | 1-6 | ||||
| 02/05/1986 | H | Tennessee State | L | 64 | 86 | 7-14 | 1-6 | Louisville | Ky. | Manual Hall | |
| 02/08/1986 | H | South Carolina | L | 67 | 80 | 7-15 | 1-7 | Louisville | Ky. | Manual Hall | |
| 02/10/1986 | H | Virginia Tech | W | 91 | 76 | 8-15 | 2-7 | Louisville | Ky. | Manual Hall | |
| 02/14/1986 | A | Kentucky | L | 77 | 87 | 8-16 | 2-7 | ||||
| 02/18/1986 | A | Vanderbilt | L | 76 | 114 | 8-17 | 2-7 | ||||
| 02/22/1986 | H | Cincinnati | L | 72 | 81 | 8-18 | 2-8 | Louisville | Ky. | Manual Hall | |
| 02/24/1986 | H | Dayton | L | 53 | 65 | 8-19 | 2-8 | Louisville | Ky. | Freedom Hall | |
| 03/01/1986 | N | Memphis | L | 63 | 99 | 8-20 | 2-8 | 1986 Metro Tournament |