Head Coach: Peggy Fiehrer Record: 14-14 (0-0 Metro)
| Date | Site | Opponent | W/L | UL | Opp | Overall | Conf | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/28/1980 | N | Fordham | W | 101 | 55 | 1-0 | 0-0 | 1980 Gold Country Thanksgiving Tournament | |||
| 11/29/1980 | A | Minnesota | L | 72 | 101 | 1-1 | 0-0 | 1980 Gold Country Thanksgiving Tournament | |||
| 12/01/1980 | A | Western Kentucky | W | 80 | 73 | 2-1 | 0-0 | ||||
| 12/05/1980 | A | Southern Illinois | L | 64 | 69 | 2-2 | 0-0 | ||||
| 12/06/1980 | A | Murray State | W | 82 | 75 | 3-2 | 0-0 | ||||
| 12/09/1980 | A | Memphis | L | 87 | 98 | 3-3 | 0-0 | ||||
| 12/13/1980 | H | Michigan | W | 89 | 80 | 4-3 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 12/17/1980 | A | Indiana State | L | 63 | 72 | 4-4 | 0-0 | ||||
| 12/20/1980 | H | Eastern Kentucky | L | 66 | 75 | 4-5 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 01/08/1981 | H | Kentucky | L | 66 | 88 | 4-6 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 01/10/1981 | A | Virginia Tech | W | 89 | 72 | 5-6 | 0-0 | ||||
| 01/13/1981 | H | Eastern Kentucky | L | 68 | 77 | 5-7 | 0-0 | Louisville | Ky. | Manual High School | |
| 01/15/1981 | A | Northern Kentucky | L | 61 | 72 | 5-8 | 0-0 | ||||
| 01/17/1981 | H | Marshall | W | 71 | 61 | 6-8 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 01/18/1981 | H | Cincinnati | W | 77 | 67 | 7-8 | 0-0 | Louisville | Ky. | Manual High School | |
| 01/27/1981 | H | South Carolina | L | 62 | 80 | 7-9 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 01/29/1981 | H | Northern Kentucky | L | 64 | 66 | 7-10 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 01/31/1981 | H | Clemson | L | 77 | 78 | 7-11 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 02/02/1981 | H | Murray State | W | 77 | 67 | 8-11 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 02/05/1981 | N | Virginia Tech | W | 81 | 64 | 9-11 | 0-0 | 1981 Metro Tournament | |||
| 02/06/1981 | N | Cincinnati | W | 83 | 76 | 10-11 | 0-0 | 1981 Metro Tournament | |||
| 02/07/1981 | N | Memphis | W | 69 | 66 | 11-11 | 0-0 | 1981 Metro Tournament | |||
| 02/10/1981 | A | Morehead State | L | 73 | 79 | 11-12 | 0-0 | ||||
| 02/14/1981 | A | Kentucky | L | 59 | 83 | 11-13 | 0-0 | ||||
| 02/16/1981 | H | Morehead State | W | 73 | 68 | 12-13 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 02/18/1981 | H | Indiana | W | 79 | 66 | 13-13 | 0-0 | Louisville | Ky. | Freedom Hall | |
| 02/20/1981 | A | Chattanooga | L | 72 | 108 | 13-14 | 0-0 | ||||
| 02/23/1981 | H | Western Kentucky | W | 83 | 78 | 14-14 | 0-0 | Louisville | Ky. | Freedom Hall |