Head Coach: Terry Hall Record: 17-17 (0-0 Metro)
| Date | Site | Opponent | W/L | UL | Opp | OT | Overall | Conf | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/28/1979 | A | Murray State | L | 79 | 90 | 0-1 | 0-0 | |||||
| 12/01/1979 | H | Southern Illinois | W | 91 | 75 | 1-1 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 12/03/1979 | A | Bellarmine | W | 82 | 60 | 2-1 | 0-0 | |||||
| 12/04/1979 | H | Chattanooga | L | 72 | 78 | 2-2 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 12/08/1979 | H | Morehead State | W | 56 | 55 | 3-2 | 0-0 | Louisville | Ky. | Thomas Jefferson High School | ||
| 12/11/1979 | H | Kentucky | L | 57 | 76 | 3-3 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 12/15/1979 | A | Clemson | L | 83 | 91 | 3-4 | 0-0 | |||||
| 12/17/1979 | N | Saint Louis | W | 74 | 45 | 4-4 | 0-0 | 1979 Metro Tournament | ||||
| 12/18/1979 | A | Florida State | W | 86 | 67 | 5-4 | 0-0 | 1979 Metro Tournament | ||||
| 12/19/1979 | N | Memphis | W | 75 | 72 | 6-4 | 0-0 | 1979 Metro Tournament | ||||
| 01/03/1980 | H | Murray State | W | 82 | 70 | 7-4 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 01/05/1980 | H | Indiana State | W | 79 | 42 | 8-4 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 01/07/1980 | A | Western Kentucky | W | 52 | 50 | 9-4 | 0-0 | |||||
| 01/09/1980 | A | Miami, Ohio | L | 67 | 69 | 9-5 | 0-0 | |||||
| 01/12/1980 | A | Cincinnati | L | 56 | 59 | 9-6 | 0-0 | |||||
| 01/14/1980 | A | Marshall | L | 56 | 60 | 9-7 | 0-0 | |||||
| 01/17/1980 | A | South Carolina | L | 43 | 98 | 9-8 | 0-0 | |||||
| 01/19/1980 | A | Tulane | W | 72 | 61 | 10-8 | 0-0 | |||||
| 01/22/1980 | H | Dayton | L | 55 | 85 | 10-9 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 01/27/1980 | H | Florida State | W | 77 | 60 | 11-9 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 01/29/1980 | A | Michigan | L | 86 | 89 | OT | 11-10 | 0-0 | ||||
| 01/31/1980 | H | Northern Kentucky | L | 75 | 79 | 11-11 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 02/02/1980 | H | Illinois | W | 74 | 64 | 12-11 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 02/04/1980 | H | Memphis | L | 62 | 66 | 12-12 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 02/06/1980 | H | Western Kentucky | W | 55 | 44 | 13-12 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 02/08/1980 | A | Northern Kentucky | W | 75 | 50 | 14-12 | 0-0 | |||||
| 02/12/1980 | A | Eastern Kentucky | W | 53 | 51 | 15-12 | 0-0 | |||||
| 02/14/1980 | A | Morehead State | L | 67 | 71 | 15-13 | 0-0 | |||||
| 02/16/1980 | A | Kentucky | L | 64 | 83 | 15-14 | 0-0 | |||||
| 02/18/1980 | H | Eastern Kentucky | W | 85 | 57 | 16-14 | 0-0 | Louisville | Ky. | Freedom Hall | ||
| 02/22/1980 | A | Indiana | L | 69 | 76 | 16-15 | 0-0 | |||||
| 02/28/1980 | N | Western Kentucky | W | 72 | 64 | 17-15 | 0-0 | 1980 KWIC State Tournament | ||||
| 02/29/1980 | A | Kentucky | L | 54 | 85 | 17-16 | 0-0 | 1980 KWIC State Tournament | ||||
| 03/01/1980 | N | Northern Kentucky | L | 86 | 88 | 17-17 | 0-0 | 1980 KWIC State Tournament |